Hughes E, Hodder R V
J Reprod Med. 1987 Jul;32(7):553-7.
A 32-year-old primigravida presented with cough and dyspnea at 16 weeks' gestation. Chest roentgenogram revealed a large pleural effusion and diffuse interstitial infiltrates. Moderate arterial hypoxemia and a significant reduction in vital capacity were present. Thoracentesis revealed sterile chyle with no evidence of malignancy. Spontaneous delivery of a healthy infant occurred at 38 weeks, but no change was seen in either the pulmonary infiltrates or chylothorax. Open lung biopsy confirmed the clinical impression of pulmonary lymphangiomyomatosis, and a pleurodesis was performed. Progesterone and estrogen receptor assays on the lung biopsy material revealed only minimal binding. Following two years of therapy with tamoxifen citrate and megestrol acetate, the chylothorax has not recurred, and there has been no other appreciable change in pulmonary function.
一名32岁初产妇在妊娠16周时出现咳嗽和呼吸困难。胸部X线片显示大量胸腔积液和弥漫性间质浸润。存在中度动脉低氧血症和肺活量显著降低。胸腔穿刺抽出无菌乳糜液，无恶性肿瘤证据。孕38周时自然分娩出一名健康婴儿，但肺部浸润或乳糜胸均无变化。开胸肺活检证实了肺淋巴管平滑肌瘤病的临床诊断，并进行了胸膜固定术。对肺活检材料进行的孕酮和雌激素受体检测仅显示微量结合。在用枸橼酸他莫昔芬和醋酸甲地孕酮治疗两年后，乳糜胸未再复发，肺功能也没有其他明显变化。
