人乳头瘤病毒感染在宫颈病变中的分布情况。
HPV infection profile in cervical lesions.
机构信息
Department of Medicine and Nutrition, Division of Health Sciences, Universidad de Guanajuato, Campus León, Guanajuato.
Dysplasia Clinic, Hospital General Regional de León, Guanajuato.
出版信息
Gac Med Mex. 2022;158(4):222-228. doi: 10.24875/GMM.M22000679.
INTRODUCTION
The prevalence of the different genotypes of human papillomavirus (HPV) varies depending on lesion severity and geographic region.
OBJECTIVE
To identify multiple HPV infections in low- and high-grade cervical lesions in a group of women from the Mexican Bajío region referred with inconclusive cytology.
METHODS
Pilot study of women referred from primary care units of Guanajuato, Mexico, with cytology suggestive of cervical lesion. Cervical smears were subjected to DNA extraction and HPV genotyping using microarrays.
RESULTS
100 consecutive cases were collected and 90 were analyzed; HPV positivity was observed in 26% of healthy women, and 62% had some degree of cervical lesion. The most common HPV genotypes were 59, 31, 16 and 51. Multiple infections were found in most samples.
CONCLUSIONS
HPV heterogeneity was identified in the samples of the study population in contrast to worldwide reports; furthermore, multiple infections are common in precursor lesions and decrease in high-grade lesions. These data could have an impact on current HPV vaccination programs.
简介
人乳头瘤病毒（HPV）的不同基因型的流行情况因病变严重程度和地理位置而异。
目的
在一组因细胞学检查结果不明确而转诊的来自墨西哥巴希奥地区的女性中，确定低度和高度宫颈病变中的多重 HPV 感染。
方法
对来自墨西哥瓜纳华托州初级保健单位的细胞学提示宫颈病变的女性进行试点研究。宫颈涂片进行 DNA 提取和微阵列 HPV 基因分型。
结果
共收集了 100 例连续病例，其中 90 例进行了分析；在 26%的健康女性中观察到 HPV 阳性，62%的女性有不同程度的宫颈病变。最常见的 HPV 基因型是 59、31、16 和 51。大多数样本中都发现了多重感染。
结论
与全球报告相比，研究人群的样本中存在 HPV 异质性；此外，在癌前病变中常见多重感染，而在高级别病变中则减少。这些数据可能对当前的 HPV 疫苗接种计划产生影响。
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