Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Maternal and Child Health Care Hospital affiliated to Qingdao University, Jinan, China.
Research Center of Traditional Chinese Medicine and Clinical Pharmacy, Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
Medicine (Baltimore). 2023 Oct 13;102(41):e34989. doi: 10.1097/MD.0000000000034989.
The previous research has found that human papillomavirus (HPV) infection is the main cause of cervical cancer, but it is still unclear whether HPV infection, as well as the HPV genotypes, are related to reproductive tract infections in the Chinese population. Patients who underwent HPV screening at Shandong Maternal and Child Health Hospital were selected, and the HPV infection status was analyzed among patients with cervical lesions, bacterial vaginosis, cervical inflammation, fungal vaginitis, and pelvic infections. SPSS 22 statistical analysis was used to analyze the differences in HPV infection types and rates between the control group and the experimental group. The HPV infection rate of bacterial vaginosis (χ2 = 13.4; P < .001) and fungal vaginitis (χ2 = 3.3; P < .045) are both significantly different from the control group. The single HPV infections reveals significant differences from control group in bacterial vaginosis (χ2 = 7.3; P = .004), fungal vaginitis (χ2 = 4.5; P = .023), and cervical lesions (χ2 = 58.8; P < .001). In the bacterial infection group, HPV51 (1.9%; χ2 = 6.0; P = .008) and HPV58 (4.7%; χ2 = 3.3; P = .044) showed significant differences in infection compared to the control group. In the fungal infection group, HPV39 (2.7%; χ2 = 4.7; P = .032) showed a significant difference in infection compared to the control group. Cervical lesions, bacterial vaginosis, fungal vaginitis, and cervical lesions among Chinese population exhibit age-specified distribution. HPV infection rate in bacterial vaginitis, fungal vaginitis and cervical lesions was higher than that in normal group. HPV52 and HPV16 infection are different, and HPV39 is different between bacterial vaginitis and fungal vaginitis.
先前的研究发现，人乳头瘤病毒（HPV）感染是宫颈癌的主要病因，但 HPV 感染以及 HPV 基因型是否与中国人群的生殖道感染有关仍不清楚。本研究选取在山东妇幼保健院进行 HPV 筛查的患者，分析宫颈病变、细菌性阴道炎、宫颈炎、霉菌性阴道炎和盆腔炎患者的 HPV 感染状况。采用 SPSS 22 统计分析软件对对照组和实验组的 HPV 感染类型和感染率进行差异分析。细菌性阴道炎（χ2=13.4；P<0.001）和霉菌性阴道炎（χ2=3.3；P<0.045）的 HPV 感染率与对照组相比均有显著差异。单一 HPV 感染与细菌性阴道炎（χ2=7.3；P=0.004）、霉菌性阴道炎（χ2=4.5；P=0.023）和宫颈病变（χ2=58.8；P<0.001）相比均有显著差异。在细菌感染组中，HPV51（1.9%；χ2=6.0；P=0.008）和 HPV58（4.7%；χ2=3.3；P=0.044）的感染与对照组相比有显著差异。在真菌感染组中，HPV39（2.7%；χ2=4.7；P=0.032）的感染与对照组相比有显著差异。中国人群的宫颈病变、细菌性阴道炎、霉菌性阴道炎和宫颈炎呈年龄特异性分布。细菌性阴道炎、霉菌性阴道炎和宫颈炎的 HPV 感染率高于正常组。HPV52 和 HPV16 的感染不同，细菌性阴道炎和霉菌性阴道炎的 HPV39 也不同。
