O'Donnell L, O'Meara N, Owens D, Johnson A, Collins P, Tomkin G
J R Soc Med. 1987 Jun;80(6):339-42. doi: 10.1177/014107688708000605.
Changes in plasma catecholamines, lipoproteins and dietary intake were examined in 13 medical students during a 3-month period prior to their examinations, and in 12 controls. In the medical students mean +/- s.e.(mean) plasma cholesterol increased over the study period (3.98 +/- 0.16 v. 4.26 +/- 0.16 mmol/l, P less than 0.05) and this was reflected by a rise in low-density lipoprotein cholesterol (2.53 +/- 0.15 v. 2.71 +/- 0.17 mmol/l, P less than 0.05). Both supine adrenaline (0.45 +/- 0.05 v. 0.70 +/- 0.07 nmol/l, P less than 0.01) and noradrenaline (2.74 +/- 0.18 v. 3.40 +/- 0.31 nmol/l, P less than 0.05) increased over this period. Apart from a decline in the modest alcohol consumption (9.1 +/- 3.45 v. 2.6 +/- 1.4 g/day, P less than 0.02) there was no change in dietary intake in the medical students. There were no significant changes in plasma catecholamines, lipoproteins or dietary intake in control subjects over the study period. Changes in catecholamines and lipoproteins occurring in association with chronic psychological stress may contribute to the increased coronary heart disease mortality associated with Type A behaviour and stressful life events.
对13名医科学生在考试前3个月期间以及12名对照者的血浆儿茶酚胺、脂蛋白和饮食摄入变化进行了检测。在医科学生中，整个研究期间血浆胆固醇均值±标准误（均值）升高（3.98±0.16对4.26±0.16 mmol/L，P<0.05），这反映在低密度脂蛋白胆固醇升高上（2.53±0.15对2.71±0.17 mmol/L，P<0.05）。在此期间，仰卧位肾上腺素（0.45±0.05对0.70±0.07 nmol/L，P<0.01）和去甲肾上腺素（2.74±0.18对3.40±0.31 nmol/L，P<0.05）均升高。医科学生除了适度饮酒量下降（9.1±3.45对2.6±1.4 g/天，P<0.02）外，饮食摄入没有变化。在研究期间，对照者的血浆儿茶酚胺、脂蛋白或饮食摄入没有显著变化。与慢性心理应激相关的儿茶酚胺和脂蛋白变化可能导致与A型行为和应激性生活事件相关的冠心病死亡率增加。
