• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Indazoles as indole bioisosteres: synthesis and evaluation of the tropanyl ester and amide of indazole-3-carboxylate as antagonists at the serotonin 5HT3 receptor.

作者信息

Fludzinski P, Evrard D A, Bloomquist W E, Lacefield W B, Pfeifer W, Jones N D, Deeter J B, Cohen M L

出版信息

J Med Chem. 1987 Sep;30(9):1535-7. doi: 10.1021/jm00392a001.

DOI:10.1021/jm00392a001
PMID:3625701
Abstract
摘要

相似文献

1
Indazoles as indole bioisosteres: synthesis and evaluation of the tropanyl ester and amide of indazole-3-carboxylate as antagonists at the serotonin 5HT3 receptor.作为吲哚生物电子等排体的吲唑：吲唑-3-羧酸酯的托烷酯和酰胺作为5-羟色胺5HT3受体拮抗剂的合成与评价
J Med Chem. 1987 Sep;30(9):1535-7. doi: 10.1021/jm00392a001.
2
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.氚标记的1-甲基-N-（8-甲基-8-氮杂双环[3.2.1]辛-3-基）-1H-吲唑-3-甲酰胺的合成及生化评价，一种用于5HT3受体的有用放射性配体。
J Med Chem. 1990 Dec;33(12):3176-81. doi: 10.1021/jm00174a013.
3
5-Hydroxytryptamine (5-HT3) receptor antagonists. 3. Ortho-substituted phenylureas.5-羟色胺（5-HT3）受体拮抗剂。3. 邻位取代的苯基脲类化合物。
J Med Chem. 1990 Jul;33(7):1932-5. doi: 10.1021/jm00169a018.
4
5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives.5-羟色胺（5-HT3）受体拮抗剂。1. 吲唑和中氮茚-3-羧酸衍生物。
J Med Chem. 1990 Jul;33(7):1924-9. doi: 10.1021/jm00169a016.
5
5-Hydroxytryptamine (5-HT3) receptor antagonists. 2. 1-Indolinecarboxamides.5-羟色胺（5-HT3）受体拮抗剂。2. 1-吲哚啉甲酰胺类
J Med Chem. 1990 Jul;33(7):1929-32. doi: 10.1021/jm00169a017.
6
BRL 43694, a new 5HT3 receptor antagonist, prevents cisplatin-induced emesis in dogs.
Methods Find Exp Clin Pharmacol. 1989 May;11(5):361-3.
7
5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists.5-哌嗪基-3-磺酰基吲唑类化合物作为强效和选择性 5-羟色胺 6 拮抗剂。
J Med Chem. 2010 Nov 11;53(21):7639-46. doi: 10.1021/jm1007825.
8
Synthesis and biological activity of a series of aryl tropanyl esters and amides chemically related to 1H-indole-3-carboxylic acid endo 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester. Development of a 5-HT4 agonist endowed with potent antinociceptive activity.一系列与1H-吲哚-3-羧酸内型8-甲基-8-氮杂双环[3.2.1]辛-3-基酯化学相关的芳基托烷酯和酰胺的合成及生物活性。一种具有强效抗伤害感受活性的5-HT4激动剂的研发。
Arzneimittelforschung. 1993 Aug;43(8):913-8.
9
The antinociceptive effect induced by FR140423 is mediated through spinal 5-HT2A and 5-HT3 receptors.FR140423诱导的抗伤害感受作用是通过脊髓5-羟色胺2A和5-羟色胺3受体介导的。
Eur J Pharmacol. 2000 Dec 8;409(2):167-72. doi: 10.1016/s0014-2999(00)00832-3.
10
Benzoxazines. II. Synthesis, conformational analysis, and structure--activity relationships of 3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide derivatives as potent and long-acting serotonin-3 (5-HT3) receptor antagonists.苯并恶嗪。II. 3,4-二氢-2H-1,4-苯并恶嗪-8-甲酰胺衍生物作为强效长效5-羟色胺-3（5-HT3）受体拮抗剂的合成、构象分析及构效关系
Chem Pharm Bull (Tokyo). 1996 Nov;44(11):2051-60. doi: 10.1248/cpb.44.2051.

引用本文的文献

1
Development of a selective and scalable 1-indazole alkylation.一种选择性且可扩展的1-吲唑烷基化反应的开发。
RSC Adv. 2024 Feb 20;14(9):6367-6373. doi: 10.1039/d4ra00598h. eCollection 2024 Feb 14.
2
Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir.HIV-1附着抑制剂替沙韦及其膦酰氧基甲基前药福沙韦的发现中的创新。
Med Chem Res. 2021;30(11):1955-1980. doi: 10.1007/s00044-021-02787-6. Epub 2021 Sep 28.
3
Regioselective -alkylation of the 1-indazole scaffold; ring substituent and -alkylating reagent effects on regioisomeric distribution.
1-吲唑骨架的区域选择性N-烷基化；环取代基和N-烷基化试剂对区域异构体分布的影响。
Beilstein J Org Chem. 2021 Aug 2;17:1939-1951. doi: 10.3762/bjoc.17.127. eCollection 2021.
4
Crystal structure of (1,5)--(8-methyl-8-azoniabi-cyclo-[3.2.1]oct-3-yl)ammonium aqua-tri-chlorido-nitratocopper(II).（1,5）-（8-甲基-8-氮杂双环-[3.2.1]辛-3-基）铵 水合三氯硝酸铜（II）的晶体结构
Acta Crystallogr E Crystallogr Commun. 2017 Oct 20;73(Pt 11):1712-1715. doi: 10.1107/S2056989017014633. eCollection 2017 Nov 1.
5
Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases.吲哚连接的嘧啶衍生物同时抑制表皮生长因子受体和其他血管生成激酶的构效关系
PLoS One. 2015 Sep 24;10(9):e0138823. doi: 10.1371/journal.pone.0138823. eCollection 2015.
6
Bioisosteric matrices for ligands of serotonin receptors.用于血清素受体配体的生物电子等排体矩阵
ChemMedChem. 2015 Apr;10(4):601-5. doi: 10.1002/cmdc.201402563. Epub 2015 Mar 13.
7
Responses to serotonin (5HT) in isolated corpus cavernosum penis of rabbit.兔离体阴茎海绵体对5-羟色胺（5HT）的反应。
Int J Impot Res. 2003 Aug;15(4):267-71. doi: 10.1038/sj.ijir.3901004.
8
The role of serotonin in schizophrenia: an overview of the nomenclature, distribution and alterations of serotonin receptors in the central nervous system.血清素在精神分裂症中的作用：中枢神经系统中血清素受体的命名、分布及变化概述
Psychopharmacology (Berl). 1993;112(1 Suppl):S5-15. doi: 10.1007/BF02245003.
9
5-HT3 receptor antagonists. An overview of their present status and future potential in cancer therapy-induced emesis.5-羟色胺3受体拮抗剂。其在癌症治疗引起的呕吐方面的现状及未来潜力概述
Drugs. 1991 Oct;42(4):551-68. doi: 10.2165/00003495-199142040-00002.