Faculty of Psychology and Neuroscience, Department of Neuropsychology & Psychopharmacology, EURON, Maastricht University, the Netherlands; European Graduate School of Neuroscience (EURON), the Netherlands.
Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany; European Graduate School of Neuroscience (EURON), the Netherlands.
Behav Brain Res. 2023 Feb 2;437:114161. doi: 10.1016/j.bbr.2022.114161. Epub 2022 Oct 17.
The object recognition and object location task (ORT and OLT, respectively) have been applied in preclinical research to evaluate the effects of treatments on memory. Although both tasks look quite similar, they differ with respect to the brain structures involved in the memory performance. The characterization of the memory performance in both tasks is important to understand treatment effects. Since there are no previous studies that compared strain differences in delay-dependent forgetting in both tasks, Wistar and Long Evans rats were tested in both the ORT and the OLT at different intervals. The data showed that in the ORT the delay-dependent forgetting was similar for Wistar and Long Evans rats. However, the forgetting curve was different for both strains in the OLT: the Long Evans rats the forgetting took a longer interval. This study indicates that delay-dependent forgetting in the ORT and OLT is strain and test dependent. It is suggested that before testing treatments the forgetting curve of a specific strain should be tested in this type of tasks.
物体识别和物体定位任务（ORT 和 OLT）已被应用于临床前研究，以评估治疗对记忆的影响。尽管这两个任务看起来非常相似，但它们在参与记忆表现的大脑结构方面有所不同。在这两个任务中对记忆表现进行特征描述对于理解治疗效果很重要。由于以前没有研究比较过这两个任务中延迟依赖遗忘的应变差异，因此在不同的间隔时间里，Wistar 和 Long Evans 大鼠在 ORT 和 OLT 中进行了测试。数据显示，在 ORT 中，Wistar 和 Long Evans 大鼠的延迟依赖遗忘相似。然而，两种品系在 OLT 中的遗忘曲线不同：Long Evans 大鼠的遗忘需要更长的时间间隔。本研究表明，ORT 和 OLT 中的延迟依赖遗忘具有应变和测试依赖性。建议在测试治疗方法之前，应在这种类型的任务中测试特定应变的遗忘曲线。
