A canine model for hemodynamic study of isolated corpus cavernosum.

We developed a canine model which permits hemodynamic study of the isolated corpus cavernosum. The arterial and venous flow to the corpus cavernosum was measured and pressure was measured in each corpus cavernosum separately. To provide controlled inflow to the corpora, each side was perfused separately with the aorta clamped. It was demonstrated that arterial and nerve supply to the corpus cavernosum is crossed. During unstimulated corporal perfusion, venous outflow from the corpora increased with increased perfusion rate up to a maximum of 40 ml./min. Following pelvic nerve stimulation, intracorporal pressure increased at much lower rates of perfusion. Moreover, it was noted that intracorporal pressure was not transmitted from one side to the other. Thus, in the canine model, each corpus cavernosum may act as a control for the contralateral one. The technique we used to measure venous outflow from the corpora cavernosa, previously undescribed, permits accurate depiction of the hemodynamics of penile erection.