Aoki H, Takagane H, Matsuzaka J, Banya Y, Fujioka T, Nakaya S, Kubo T, Ohhori T
Department of Urology, Iwate Medical University School of Medicine, Morioka, Japan.
J Urol. 1989 Mar;141(3):645-50. doi: 10.1016/s0022-5347(17)40924-4.
Using a pressure flow technique, quantitative analysis of the physiological characteristics of the outflow pathway of the corpus cavernosum was carried out in 19 male dogs weighing 7.5 to 23.0 kg. Pressure flow curves were made on dogs whose pelvic nerve was stimulated electrically and on dogs left unstimulated. When a cyclical change in saline perfusion rate was applied without nerve stimulation, the variable of the intracorporeal pressure showed a large hysteretic loop, indicating that the resistance of the outflow canals to flow was altered by the distension of the sinusoidal space. In dogs whose pelvic nerve was stimulated, the pressure flow curves shifted to the left side in comparison with the outward phase of the pressure flow curve of animals without pelvic nerve stimulation, and this curve piled on the returning phase. No hysteretic relation was observed between the outward and returning phase of the pressure flow curve with pelvic nerve stimulation, but in the detailed analysis, in which the % flow rate was used instead of actual flow rate of saline perfusion, a small hysteretic loop based on the difference of the elasticity of the outlet canals was found. The distension of the corpora cavernosa and the pelvic nerve electrostimulation probably act as the triggers of the same occlusive mechanism in the outflow pathway. The percentage decrease in the blood flow in the outflow canal of the corpus cavernosum induced by the distension of the sinusoidal space or by the pelvic nerve electrostimulation was 69.6 +/- 14.4% (mean +/- SD).
采用压力流技术，对19只体重在7.5至23.0千克之间的雄性犬阴茎海绵体流出道的生理特征进行了定量分析。对电刺激盆神经的犬和未受刺激的犬进行了压力流曲线测定。在无神经刺激的情况下，当对生理盐水灌注速率施加周期性变化时，体内压力变量显示出一个大的滞后环，这表明流出通道对血流的阻力因海绵窦空间的扩张而改变。在盆神经受刺激的犬中，与未刺激盆神经的动物压力流曲线的外向相相比，压力流曲线向左移位，且该曲线与返回相重叠。在盆神经刺激下，压力流曲线的外向相和返回相之间未观察到滞后关系，但在详细分析中，用灌注生理盐水的百分比流速代替实际流速时，发现基于流出通道弹性差异的一个小滞后环。阴茎海绵体的扩张和盆神经电刺激可能是流出道中同一闭塞机制的触发因素。由海绵窦空间扩张或盆神经电刺激引起的阴茎海绵体流出道血流减少百分比为69.6±14.4%（平均值±标准差）。
