Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Physiol Rep. 2022 Oct;10(20):e15488. doi: 10.14814/phy2.15488.
Colorectal cancer (CRC) is the third most prevalent cancer in relation to incidence and mortality rate and its incidence is considerably increasing annually due to the change in the dietary habit and lifestyle of the world population. Although conventional therapeutic options, such as surgery, chemo- and radiotherapy have profound impacts on the treatment of CRC, dietary therapeutic agents, particularly natural products have been regarded as the safest alternatives for the treatment of CRC. Kaempferol (KMP), a naturally derived flavonol, has been shown to reduce the production of reactive oxygen species (ROS), such as superoxide ions, hydroxyl radicals, and reactive nitrogen species (RNS), especially peroxynitrite. Furthermore, this flavonol inhibits xanthine oxidase (XO) activity and increases the activities of catalase, heme oxygenase-1 (HO), and superoxide dismutase (SOD) in a wide range of cancer and non-cancer cells. Based on several studies, KMP is also a hopeful anticancer which carries out its anticancer action via suppression of angiogenesis, stimulation of apoptosis, and cell cycle arrest. Due to various applications of KMP as an anticancer flavonol, this review article aims to highlight the current knowledge regarding the role of KMP in CRC.
结直肠癌（CRC）是发病率和死亡率方面第三大常见的癌症，由于世界人口饮食和生活方式的改变，其发病率每年都在显著增加。尽管手术、化疗和放疗等传统治疗方法对 CRC 的治疗有很大的影响，但饮食治疗剂，特别是天然产物，已被视为 CRC 治疗的最安全替代品。山奈酚（KMP）是一种天然衍生的类黄酮，已被证明可以减少活性氧（ROS）的产生，如超氧阴离子、羟自由基和活性氮物种（RNS），特别是过氧亚硝酸盐。此外，这种类黄酮还可以抑制黄嘌呤氧化酶（XO）的活性，并在广泛的癌症和非癌细胞中增加过氧化氢酶、血红素加氧酶-1（HO）和超氧化物歧化酶（SOD）的活性。基于多项研究，KMP 也是一种有希望的抗癌药物，它通过抑制血管生成、刺激细胞凋亡和细胞周期停滞来发挥抗癌作用。由于 KMP 作为一种抗癌类黄酮具有多种应用，因此本文旨在强调目前关于 KMP 在 CRC 中的作用的知识。
