Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biology, Concordia University, Montreal, QC, Canada.
Curr Pharm Des. 2023;29(20):1547-1556. doi: 10.2174/1381612829666230719121548.
Obesity is considered as a chronic and high-prevalence disease on a global scale which affects all genders and ages. Although various drugs have been confirmed for the treatment of obesity, these medications have been shown to have a number of adverse effects on health. It is highlighted that natural products have an alleviative role in a broad spectrum of diseases, in particular obesity, and diabetes. Kaempferol (KMP), a plant- derived flavonol, is considerably engaged in the suppression of oxidative stress, radical scavenging, opposing cellular toxicity, and induction of the production and release of growth factors. This flavonol combats obesity by suppressing adipogenesis, regulating lipid and glucose metabolism, changing gut microbiota, and activating autophagy. Also, studies have shown that KMP exerts its anti-obesity actions by decreasing the accumulation of lipids and triglycerides (TGs), increasing fatty acid oxidation, and regulating multiple metabolic genes in the adipocytes. Considering that KMP may be a potential candidate for combating obesity, this paper summarizes the possible therapeutic roles of KMP in the treatment and prevention of this disease.
肥胖被认为是一种全球性的慢性高发性疾病，影响所有性别和年龄段。尽管已经有多种药物被证实可用于治疗肥胖症，但这些药物已被证明对健康有许多不良影响。有研究强调，天然产物在广泛的疾病中具有缓解作用，特别是肥胖症和糖尿病。山柰酚（KMP）是一种植物衍生的类黄酮，在抑制氧化应激、清除自由基、抵抗细胞毒性以及诱导生长因子的产生和释放方面具有显著作用。这种类黄酮通过抑制脂肪生成、调节脂质和葡萄糖代谢、改变肠道微生物群和激活自噬来对抗肥胖。此外，研究表明，KMP 通过减少脂质和三酸甘油脂（TGs）的积累、增加脂肪酸氧化以及调节脂肪细胞中的多种代谢基因来发挥其抗肥胖作用。鉴于 KMP 可能是对抗肥胖的潜在候选药物，本文总结了 KMP 在治疗和预防这种疾病方面的可能治疗作用。
