Variable metabolic scaling breaks the law: from 'Newtonian' to 'Darwinian' approaches.

Life's size and tempo are intimately linked. The rate of metabolism varies with body mass in remarkably regular ways that can often be described by a simple power function, where the scaling exponent (, slope in a log-linear plot) is typically less than 1. Traditional theory based on physical constraints has assumed that is 2/3 or 3/4, following natural law, but hundreds of studies have documented extensive, systematic variation in . This overwhelming, law-breaking, empirical evidence is causing a paradigm shift in metabolic scaling theory and methodology from 'Newtonian' to 'Darwinian' approaches. A new wave of studies focuses on the adaptable regulation and evolution of metabolic scaling, as influenced by diverse intrinsic and extrinsic factors, according to multiple context-dependent mechanisms, and within boundary limits set by physical constraints.