Brinton W T, Vastbinder E E, Greene J W, Marx J J, Hutcheson R H, Schaffner W
JAMA. 1987 Sep 4;258(9):1210-2.
An explosive outbreak of a febrile respiratory illness occurred among members of a college fraternity. The preponderant signs and symptoms were muscle aches, cough, and low-grade fever. All illnesses occurred within 1.3 to 13 hours of attendance at a party where there was a dense airborne dust from straw that had been laid on the floor. Of the 67 fraternity members who attended the party and answered a questionnaire, 55 became ill (attack rate, 82%). Risk of illness was higher for those who spent more time at the party. Duration of illness ranged from 4.5 hours to seven days. Results of serological studies did not demonstrate an allergic or viral cause for these illnesses. The clinical and epidemiologic features of this outbreak were characteristic of organic dust toxic syndrome, an acute respiratory illness caused by inhalation of molds growing on hay, silage, or other agricultural products.
一场发热性呼吸道疾病的爆发在一所大学兄弟会成员中发生。主要症状和体征为肌肉疼痛、咳嗽和低热。所有病例均在参加一个派对后的1.3至13小时内发病，该派对上地面铺有稻草，扬起了浓密的空气传播灰尘。在67名参加派对并回答问卷的兄弟会成员中，55人患病（罹患率为82%）。在派对上停留时间更长的人患病风险更高。病程从4.5小时至7天不等。血清学研究结果未显示这些疾病的病因是过敏或病毒。此次疫情的临床和流行病学特征符合有机粉尘中毒综合征，这是一种因吸入干草、青贮饲料或其他农产品上生长的霉菌而引起的急性呼吸道疾病。
