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一项回顾性队列研究比较了在欧洲税收为基础的医疗保健系统(THS)与社会健康保险系统中治疗的年龄≥70 岁的危重症患者在 30 天死亡率方面的差异。

A retrospective cohort study comparing differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in European tax-based healthcare systems (THS) versus social health insurance systems.

机构信息

Center for Public Health and Healthcare Research, Paracelsus Medical University of Salzburg, 5020, Salzburg, Austria.

Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, 5020, Salzburg, Austria.

出版信息

Sci Rep. 2022 Oct 19;12(1):17460. doi: 10.1038/s41598-022-21580-y.

Abstract

In Europe, tax-based healthcare systems (THS) and social health insurance systems (SHI) coexist. We examined differences in 30-day mortality among critically ill patients aged ≥ 70 years treated in intensive care units in a THS or SHI. Retrospective cohort study. 2406 (THS n = 886; SHI n = 1520) critically ill ≥ 70 years patients in 129 ICUs. Generalized estimation equations with robust standard errors were chosen to create population average adjusted odds ratios (aOR). Data were adjusted for patient-specific variables, organ support and health economic data. The primary outcome was 30-day-mortality. Numerical differences between SHI and THS in SOFA scores (6 ± 3 vs. 5 ± 3; p = 0.002) were observed, but clinical frailty scores were similar (> 4; 17% vs. 14%; p = 0.09). Higher rates of renal replacement therapy (18% vs. 11%; p < 0.001) were found in SHI (aOR 0.61 95%CI 0.40-0.92; p = 0.02). No differences regarding intubation rates (68% vs. 70%; p = 0.33), vasopressor use (67% vs. 67%; p = 0.90) and 30-day-mortality rates (47% vs. 50%; p = 0.16) were found. Mortality remained similar between both systems after multivariable adjustment and sensitivity analyses. The retrospective character of this study. Baseline risk and mortality rates were similar between SHI and THS. The type of health care system does not appear to have played a role in the intensive care treatment of critically ill patients ≥ 70 years with COVID-19 in Europe.

摘要

在欧洲,税收为基础的医疗保健系统(THS)和社会健康保险系统(SHI)并存。我们研究了在 THS 或 SHI 中接受重症监护治疗的年龄≥70 岁的危重病患者 30 天死亡率的差异。回顾性队列研究。在 129 个 ICU 中,有 2406 名年龄≥70 岁的危重病患者(THS 组 n=886;SHI 组 n=1520)。选择广义估计方程和稳健标准误差来创建人群平均调整后的优势比(aOR)。数据调整了患者特定变量、器官支持和健康经济数据。主要结局是 30 天死亡率。观察到 SHI 和 THS 之间 SOFA 评分的数值差异(6±3 与 5±3;p=0.002),但临床脆弱性评分相似(>4;17%与 14%;p=0.09)。SHI 中发现更高的肾脏替代治疗率(18%与 11%;p<0.001)(aOR 0.61 95%CI 0.40-0.92;p=0.02)。插管率(68%与 70%;p=0.33)、血管加压素使用率(67%与 67%;p=0.90)和 30 天死亡率(47%与 50%;p=0.16)无差异。多变量调整和敏感性分析后,两种系统之间的死亡率仍然相似。这项研究的回顾性特征。SHI 和 THS 之间的基线风险和死亡率相似。在欧洲,医疗保健系统的类型似乎在 COVID-19 危重病患者≥70 岁的重症监护治疗中没有发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c298/9582023/b8d0fc5a43da/41598_2022_21580_Fig1_HTML.jpg

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