Sakaue H, Negi A, Matsumura M, Ohkuma M, Honda Y
Jpn J Ophthalmol. 1987;31(1):109-13.
Spontaneous retinal degeneration of Celestial goldfish was studied histologically and electrophysiologically. Retinal degeneration was divided into three stages. Until the age of 75 days (Stage 0) the retina showed normal histological development and the electroretinograms (ERGs) exhibited dominant b-waves similar to those of adult common goldfish. By the age of 105 days (Stage 1), when the eyeballs began to protrude laterally, histological changes were first observed in the retinal pigment epithelium and photoreceptor layer. The b-wave amplitude decreased to 52% of that of Stage 0 with a prolongation of the peak latency. By the age of 135 days (Stage 2), when eyeballs protruded further anterodorsally, the retinal degeneration extended to the entire retinal layers and no b-waves were detected. The deterioration of the b-wave amplitude was closely correlated to the histological findings of retinal degeneration. The Celestial goldfish is considered to be a new model of hereditary retinal degeneration.
对朝天眼金鱼的自发性视网膜变性进行了组织学和电生理学研究。视网膜变性分为三个阶段。在75日龄之前（0期），视网膜显示出正常的组织学发育，视网膜电图（ERG）表现出与成年普通金鱼相似的优势b波。到105日龄（1期）时，眼球开始向外侧突出，视网膜色素上皮和光感受器层首次出现组织学变化。b波振幅降至0期的52%，峰值潜伏期延长。到135日龄（2期）时，眼球进一步向前背侧突出，视网膜变性扩展至整个视网膜层，未检测到b波。b波振幅的恶化与视网膜变性的组织学结果密切相关。朝天眼金鱼被认为是遗传性视网膜变性的一种新模型。
