多囊卵巢综合征患者供卵受者后代的妊娠结局及随访。

Pregnancy outcome and follow-up of offspring of donor oocytes recipient from PCOS patients.

机构信息

The Center for Reproductive Medicine and Infertility, The Fourth Hospital of Shijiazhuang, Shijiazhuang Obstetrics and Gynecology Hospital affiliated to Hebei Medical University, 206 Zhong-Shan-Dong, Shijiazhuang, Hebei, 050011, People's Republic of China.

出版信息

BMC Pregnancy Childbirth. 2022 Oct 19;22(1):779. doi: 10.1186/s12884-022-05114-y.

DOI:10.1186/s12884-022-05114-y

PMID:36261799

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9580140/

Abstract

BACKGROUND

The use of donated oocytes (DO) for in vitro fertilization(IVF) treatment in patients with infertility is generally recognized, and females with polycystic ovarian syndrome (PCOS) can participate in oocyte donation programs as donor patients. However, the pregnancy outcomes and offspring follow-up in patients with PCOS as the recipients are unclear. This study was to compare the pregnancy outcomes and follow-up of offspring in PCOS and non-PCOS receptor.

METHODS

This was a retrospective cohort study of 62 patients undergoing the oocyte reception program were separated into 2 groups: Group I, PCOS oocyte recipients (n = 30); Group II, non-PCOS recipients (n = 32). Medical records were reviewed, and rates of fertilization, cleavage, high-quality embryos and blastocysts were compared between PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, multiple pregnancies, and offspring outcomes were calculated using the first single vitrified-warmed blastocyst transfer (SVBT) analysis between the groups.

RESULTS

The average recipient age and body mass index (BMI) of PCOS and non-PCOS patients was (36.3 ± 2.6 vs. 36.2 ± 2.8, and 23.4 ± 3.9 vs. 23.7 ± 4.0), respectively (P > 0.05). The fertilization, cleavage, high-quality embryos and blastocyst rates were not significantly different between the PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, and multiple pregnancies were not significantly different in SVBT between the PCOS and non-PCOS groups. The incidence of complications, such as pre-eclampsia or gestational diabetes, between PCOS and non-PCOS groups was similar (11.8% vs.11.1%, 5.9% vs.5.5%; P > 0.05). Preterm births were also similar (11.8% vs.16.7%, P > 0.05). Donor oocytes are more likely to be delivered via cesarean Sect. (80.0% vs. 86.7%: P > 0.05). The mean gestational age, birth weight, and height were comparable between the 2 groups during full-term delivery.

CONCLUSION

There was no difference in the pregnancy outcomes and follow-up of the offspring between the PCOS and non-PCOS groups.

摘要

背景

使用捐赠的卵子（DO）进行体外受精（IVF）治疗在不孕患者中是普遍认可的，患有多囊卵巢综合征（PCOS）的女性可以作为供体患者参与卵子捐赠计划。然而，PCOS 患者作为受体的妊娠结局和后代随访情况尚不清楚。本研究旨在比较 PCOS 和非 PCOS 受体患者的妊娠结局和后代随访情况。

方法

这是一项回顾性队列研究，纳入了 62 名接受卵母细胞接收计划的患者，将其分为两组：I 组，PCOS 卵母细胞受体（n=30）；II 组，非 PCOS 受体（n=32）。回顾了病历，并比较了 PCOS 和非 PCOS 组之间的受精、卵裂、优质胚胎和囊胚率。使用两组之间的首次单冷冻解冻囊胚转移（SVBT）分析计算了着床率、妊娠率、异位妊娠率、早期流产率、多胎妊娠率和后代结局。

结果

PCOS 和非 PCOS 患者的平均受体年龄和体重指数（BMI）分别为（36.3±2.6 岁 vs. 36.2±2.8 岁，和 23.4±3.9 岁 vs. 23.7±4.0 岁）（P>0.05）。PCOS 和非 PCOS 组之间的受精、卵裂、优质胚胎和囊胚率无显著差异。SVBT 两组之间的着床率、妊娠率、异位妊娠率、早期流产率和多胎妊娠率无显著差异。PCOS 和非 PCOS 组之间的并发症发生率，如子痫前期或妊娠期糖尿病，相似（11.8% vs.11.1%，5.9% vs.5.5%；P>0.05）。早产率也相似（11.8% vs.16.7%，P>0.05）。供体卵母细胞更有可能通过剖宫产分娩（80.0% vs.86.7%：P>0.05）。在足月分娩时，两组的平均胎龄、出生体重和身高相当。