Tiebosch A T, Wolters J, Frederik P F, van der Wiel T W, Zeppenfeldt E, van Breda Vriesman P J
Kidney Int. 1987 Jul;32(1):112-6. doi: 10.1038/ki.1987.179.
In this study incidence rates of idiopathic glomerular disease in 1.5 X 10(6) Dutch adults between 16 and 65 years of age were determined, as well as the prevalence of these diseases in terms of indication for renal biopsy. The study was conducted between 1978 and 1985; indications for renal biopsy in decreasing hierarchical order were recently discovered uremia, nephrotic syndrome, chronic hematuria of less than two years duration with or without proteinuria or disturbed renal function, and chronic proteinuria of less than two years duration, of unknown origin. The main findings are fourfold. The incidence of IgA nephropathy and thin glomerular basal membrane lesions was high, 19 and 13 per 10(6) adults respectively, and the prevalence in patients biopsied because of non-azotemic chronic hematuria was 31% and 22%, respectively. In the normotensive non-azotemic adults biopsied because of chronic, mild proteinuria the prevalence of focal segmental glomerular sclerosis and vascular hyalinosis was both 41%. Of the patients biopsied because of nephrotic syndrome the prevalence of membranoproliferative glomerulonephritis (5%) was low, as was the incidence (less than 2 per 10(6) adults per year). Finally, the prevalence of diffuse sclerosing glomerulonephritis was 25% in patients biopsied because of uremia. This study is useful for the differential diagnosis of idiopathic glomerular disease.
在本研究中，确定了150万16至65岁荷兰成年人特发性肾小球疾病的发病率，以及根据肾活检指征得出的这些疾病的患病率。该研究在1978年至1985年期间进行；肾活检指征按等级递减顺序依次为：最近发现的尿毒症、肾病综合征、病程少于两年的慢性血尿伴或不伴蛋白尿或肾功能紊乱，以及病程少于两年、病因不明的慢性蛋白尿。主要研究结果有四点。IgA肾病和薄肾小球基底膜病变的发病率较高，分别为每100万成年人中有19例和13例，因非氮质血症性慢性血尿接受活检的患者中，其患病率分别为31%和22%。在因慢性轻度蛋白尿接受活检的血压正常的非氮质血症成年人中，局灶节段性肾小球硬化和血管玻璃样变的患病率均为41%。在因肾病综合征接受活检的患者中，膜增生性肾小球肾炎的患病率较低（5%），发病率也较低（每年每100万成年人中少于2例）。最后，因尿毒症接受活检的患者中，弥漫性硬化性肾小球肾炎的患病率为25%。这项研究对特发性肾小球疾病的鉴别诊断很有帮助。
