分析弥漫大 B 细胞淋巴瘤患者血清中碱性成纤维细胞生长因子与临床病理疗效及国际预后指数的相关性。
Analysis of the Correlation of Basic Fibroblast Growth Factor in Serum of Patients with Diffuse Large B-Cell Lymphoma with Clinicopathological Efficacy and International Prognostic Index.
机构信息
Department of Clinical Laboratory, Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University, Huai'an 223400, China.
Department of Radiotherapy, Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University, Huai'an 223400, China.
出版信息
Contrast Media Mol Imaging. 2022 Sep 19;2022:8311535. doi: 10.1155/2022/8311535. eCollection 2022.
The correlation of basic fibroblast growth factor (bFGF) in serum of patients with diffuse large B-cell lymphoma (DLBCL) with clinicopathological efficacy and International Prognostic Index (IPI) is analyzed. 115 DLBCL patients admitted to our hospital for treatment from June 2020 to June 2021 are selected as the DLBCL patient group, 65 healthy subjects who received physical examination in our hospital during the same period are selected as the healthy control group, and the serum bFGF levels of DLBCL group and healthy control group are observed before treatment. The experimental results show that the serum bFGF expression of DLBCL patients is decreased significantly after chemotherapy, and the serum bFGF expression of DLBCL patients is closely related to the treatment effect, disease progression, tumor invasion, and prognosis, which has important clinical significance for judging the disease, treatment effect, and prognosis of patients.
分析了弥漫性大 B 细胞淋巴瘤（DLBCL）患者血清中碱性成纤维细胞生长因子（bFGF）与临床病理疗效和国际预后指数（IPI）的相关性。选取 2020 年 6 月至 2021 年 6 月我院收治的 115 例 DLBCL 患者作为 DLBCL 患者组，选取同期我院体检的 65 例健康者作为健康对照组，观察 DLBCL 组和健康对照组治疗前的血清 bFGF 水平。实验结果表明，化疗后 DLBCL 患者血清 bFGF 表达明显下降，DLBCL 患者血清 bFGF 表达与治疗效果、疾病进展、肿瘤侵袭和预后密切相关，对判断患者病情、治疗效果和预后具有重要的临床意义。
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