Li Mingxuan, Li Hongdian, Liu Hongxu, Lai Xiaolei, Xing Wenlong
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Beijing University of Chinese Medicine, Beijing, China.
Front Pharmacol. 2022 Oct 3;13:972738. doi: 10.3389/fphar.2022.972738. eCollection 2022.
. [Lamiaceae, danshen] injection classes (SMIC) is widely used in the treatment of unstable angina (UA). However, it is uncertain which SMIC is more effective in terms of UA efficacy. The purpose of this Network Meta-analysis (NMA) was to compare the treatment effects of various SMIC to determine the best SMIC for the treatment of UA. The China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), Chinese Biomedical Literature Database (CBM), PubMed, Web of Science, and Cochrane Library databases were searched to screen randomized controlled trials (RCTs) of SMIC for UA. The search time frame was all from the establishment of the database to May 2022. RevMan 5.3 and Stata 14.0 software were used for NMA. A total of 148 studies including 14,979 patients, including 7,584 cases in the experimental group and 7,395 cases in the control group were included, and eight SMIC were extracted, namely:Danshen injection, Fufang Danshen injection, Guanxinning injection, Danshenchuanxiongqin injection, Danhong injection, Danshentong IIA Huangsuanna injection, Shenxiong Putaotang injection, and Danshenduofensuanyan injection. The results of NMA showed that, in terms of total effective rate, Shenxiong Putaotang injection and Danshenchuanxiongqin injection have the advantage; In terms of ECG efficiency, Danshentong IIA Huangsuanna injection and Danshen injection have an advantage; Danshenchuanxiongqin injection and Danshenduofensuanyan injection were more effective than other SMIC in improving angina pectoris attacks; Shenxiong Putaotang injection has an advantage in improving hs-CRP; Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection have advantages in improving TC and TG, respectively. The eight SMIC included in the current study were effective in treating UA, Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection were both superior in improving all outcome indicators. However, there is still a need for larger samples and high-quality randomized controlled trials for more refined comparisons of various SMIC. : [PROSPERO], identifier [CRD42022350872].
. [唇形科，丹参]注射液类（SMIC）被广泛用于治疗不稳定型心绞痛（UA）。然而，就UA疗效而言，哪种SMIC更有效尚不确定。本网状Meta分析（NMA）的目的是比较各种SMIC的治疗效果，以确定治疗UA的最佳SMIC。检索中国知网（CNKI）、万方数据库、维普中文科技期刊数据库（VIP）、中国生物医学文献数据库（CBM）、PubMed、Web of Science和Cochrane图书馆数据库，以筛选SMIC治疗UA的随机对照试验（RCT）。检索时间范围为从各数据库建立至2022年5月。使用RevMan 5.3和Stata 14.0软件进行NMA。共纳入148项研究，包括14979例患者，其中试验组7584例，对照组7395例，并提取了8种SMIC，即：丹参注射液、复方丹参注射液、冠心宁注射液、丹参川芎嗪注射液、丹红注射液、丹参酮IIA磺酸钠注射液、参芎葡萄糖注射液和丹参多酚酸盐注射液。NMA结果显示，就总有效率而言，参芎葡萄糖注射液和丹参川芎嗪注射液具有优势；就心电图有效率而言，丹参酮IIA磺酸钠注射液和丹参注射液具有优势；丹参川芎嗪注射液和丹参多酚酸盐注射液在改善心绞痛发作方面比其他SMIC更有效；参芎葡萄糖注射液在改善超敏C反应蛋白（hs-CRP）方面具有优势；参芎葡萄糖注射液和丹参酮IIA磺酸钠注射液分别在改善总胆固醇（TC）和甘油三酯（TG）方面具有优势。本研究纳入的8种SMIC对UA均有效，参芎葡萄糖注射液和丹参酮IIA磺酸钠注射液在改善所有结局指标方面均更具优势。然而，仍需要更大样本量和高质量的随机对照试验，以便对各种SMIC进行更精细的比较。：[国际前瞻性系统评价注册库（PROSPERO）]，标识符[CRD42022350872]
