Ge Yuying, Chen Yuying, Guo Chijiao, Luo Huan, Fu Fangda, Ji Weifeng, Wu Chengliang, Ruan Hongfeng
The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
J Inflamm Res. 2022 Oct 17;15:5857-5871. doi: 10.2147/JIR.S382069. eCollection 2022.
Low back pain (LBP) is a common problem worldwide, resulting in great patient suffering and great challenges for the social health system. Intervertebral disc (IVD) degeneration (IVDD) is widely acknowledged as one of the key causes of LBP. Accumulating evidence suggests that aberrant pyroptosis of IVD cells is involved in the pathogenesis of IVDD progression, however, the comprehensive roles of pyroptosis in IVDD have not been fully established, leaving attempts to treat IVDD with anti-pyroptosis approaches questionable. In this review, we summarize the characteristics of pyroptosis and emphasize the effects of IVD cell pyroptosis on the pathological progression of IVDD, including secretion of cytokines, nucleus pulposus cell apoptosis and autophagy, accelerated extracellular matrix degradation, annulus fibrosus rupture, cartilage endplate calcification, vascularization, sensory and sympathetic fiber neoinnervation, and infiltrating lymphatic vessels. Finally, we discuss several interventions used to treat IVDD by targeting pyroptosis. This review provides novel insights into the crucial role of IVD cell pyroptosis in IVDD pathogenesis, and could be informative for developing novel therapeutic approaches for IVDD and LBP.
下腰痛（LBP）是全球范围内的常见问题，给患者带来巨大痛苦，也给社会卫生系统带来巨大挑战。椎间盘（IVD）退变（IVDD）被广泛认为是LBP的主要原因之一。越来越多的证据表明，IVD细胞异常焦亡参与了IVDD进展的发病机制，然而，焦亡在IVDD中的综合作用尚未完全明确，因此用抗焦亡方法治疗IVDD的尝试存在疑问。在本综述中，我们总结了焦亡的特征，并强调了IVD细胞焦亡对IVDD病理进展的影响，包括细胞因子分泌、髓核细胞凋亡和自噬、细胞外基质降解加速、纤维环破裂、软骨终板钙化、血管生成、感觉和交感神经纤维新生以及淋巴管浸润。最后，我们讨论了几种通过靶向焦亡来治疗IVDD的干预措施。本综述为IVD细胞焦亡在IVDD发病机制中的关键作用提供了新的见解，并可能为开发治疗IVDD和LBP的新方法提供参考。
