Chao-Yang G, Peng C, Hai-Hong Z
Lanzhou University Second Hospital, 82 Cuiying Men, Lanzhou, 730000, PR China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou, 730000, PR China.
Lanzhou University Second Hospital, 82 Cuiying Men, Lanzhou, 730000, PR China.
Osteoarthritis Cartilage. 2021 Jun;29(6):793-801. doi: 10.1016/j.joca.2021.02.204. Epub 2021 Feb 18.
Intervertebral disc degeneration (IVDD) is one of the leading causes of low back pain and one of the most common health problems in the world. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3 (NLRP3) inflammasome, as a pattern recognition receptor, has been shown to be associated with the pathological processes of many diseases in recent years. With the exploration of the mechanism of IVDD, recent studies have shown that activation of the NLRP3 inflammasome is associated with intervertebral disc (IVD) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of IVD cells. In this review, we summarize the structural characteristics of NLRP3 inflammasome and the activation signalling mechanisms. We also describe the role of the NLRP3 inflammasome in the pathological process of IVDD and the application of the targeting the NLRP3 inflammasome in IVDD treatment.
椎间盘退变（IVDD）是腰痛的主要原因之一，也是世界上最常见的健康问题之一。核苷酸结合寡聚化结构域样受体家族含pyrin结构域3（NLRP3）炎性小体作为一种模式识别受体，近年来已被证明与许多疾病的病理过程有关。随着对IVDD机制的探索，最近的研究表明，NLRP3炎性小体的激活与椎间盘（IVD）炎症、细胞焦亡、细胞外基质降解以及IVD细胞凋亡有关。在本综述中，我们总结了NLRP3炎性小体的结构特征和激活信号机制。我们还描述了NLRP3炎性小体在IVDD病理过程中的作用以及靶向NLRP3炎性小体在IVDD治疗中的应用。
