卵泡-卵母细胞指数与体外受精治疗中临床妊娠的关系：对 4323 个新鲜胚胎移植周期的回顾性研究。
Association of follicle-to-oocyte index and clinical pregnancy in IVF treatment: A retrospective study of 4,323 fresh embryo transfer cycles.
机构信息
The Assisted Reproduction Center, Huizhou Central People's Hospital, Huizhou, China.
出版信息
Front Endocrinol (Lausanne). 2022 Oct 3;13:973544. doi: 10.3389/fendo.2022.973544. eCollection 2022.
OBJECTIVE
The aim of this study is to investigate whether the follicle-to-oocyte index [FOI: (number of retrieved oocytes/antral follicle count) × 100] was associated with clinical pregnancy after fresh cleavage transfer.
DESIGN
The framework used to organize this study is retrospective cohort analysis.
SETTING
The study was performed in a single fertilization center in a public hospital.
PATIENTS
In total, 4,323 fresh embryo transfer cycles from 1 August 2011 to 31 January 2022 were retrospectively analyzed. Data were designated into three groups according to FOI tertile values.
INTERVENTIONS
There are no interventions in this study.
MAIN OUTCOME MEASURE
The primary outcome measure is the clinical pregnancy rate (CPR).
RESULTS
A total of 4,323 patients were included in the study. According to their FOI, patients were divided into low (FOI ≤ 0.70, n = 1,434), medium (FOI = 0.71-0.95, n = 1,070), and high (FOI = 0.96-1.00, n = 1,819) tertile groups. A significant statistical increase in the CPR from the lowest to the highest tertile FOI group was detected (47.28%, 51.78%, and 51.57%; =0.026). After adjusted for potential confounders, multivariate logistic regression analysis revealed a positive association between FOI and CPR [odds ratio (OR) = 1.57; 95% confidence interval (CI): 1.18-2.11]. Each standard deviation increments in FOI (SD = 0.24) corresponded to a 20% increase in the CPR. Trend analysis also showed that FOI tertile groups were positively associated with CPR ( for trend = 0.010). Smooth curve fitting indicated the existence of a linear relationship across the entire range of FOI. No optimal cutoff value of FOI for prognosing CPR was found in smooth curve fitting analysis. Moreover, subgroup analyses suggested that the association was significantly stronger in the single cleavage transfer cycle (OR = 2.04; 95% CI: 1.14-3.65).
CONCLUSIONS
FOI is an independent variable in prediction for CPR in fresh embryo transfer cycle, especially in the single cleavage transfer cycle.
目的
本研究旨在探讨滤泡-卵母细胞指数（FOI：[获卵数/窦卵泡数]×100）与新鲜卵裂期胚胎移植后的临床妊娠率是否相关。
设计
本研究采用回顾性队列分析。
设置
该研究在一家公立医院的一家受精中心进行。
患者
2011 年 8 月 1 日至 2022 年 1 月 31 日共回顾性分析了 4323 个新鲜胚胎移植周期的数据。根据 FOI 三分位值将数据分为三组。
干预措施
本研究无干预措施。
主要观察指标
主要观察指标是临床妊娠率（CPR）。
结果
共纳入 4323 例患者。根据 FOI，患者分为低（FOI≤0.70，n=1434）、中（FOI=0.71-0.95，n=1070）和高（FOI=0.96-1.00，n=1819）三分位组。从 FOI 最低到最高三分位组，CPR 显著升高（47.28%、51.78%和 51.57%；=0.026）。调整潜在混杂因素后，多因素逻辑回归分析显示 FOI 与 CPR 呈正相关（比值比[OR]=1.57；95%置信区间[CI]：1.18-2.11）。FOI 每增加一个标准差（SD=0.24），CPR 增加 20%。趋势分析也表明 FOI 三分位组与 CPR 呈正相关（趋势检验=0.010）。平滑曲线拟合表明，在整个 FOI 范围内存在线性关系。在平滑曲线拟合分析中，未发现预测 CPR 的 FOI 最佳截断值。此外，亚组分析表明，该关联在单卵裂期胚胎移植周期中更为显著（OR=2.04；95%CI：1.14-3.65）。
结论
FOI 是新鲜胚胎移植周期中预测 CPR 的一个独立变量，尤其是在单卵裂期胚胎移植周期中。
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