Roque Matheus, Sunkara Sesh K
Mater Prime - Reproductive Medicine, Av. Ibirapuera, 2315 - Moema, São Paulo, 04029-200, SP, Brazil.
King's College London, London, UK.
Reprod Biol Endocrinol. 2025 Jan 9;23(Suppl 1):5. doi: 10.1186/s12958-024-01331-6.
Ovarian stimulation (OS) is a crucial component of clinical IVF treatment that strongly influences outcomes. As such, it is useful to understand the indicators for successful OS during IVF. As OS leads to multiple follicular recruitment, it can be quantified as number of oocytes retrieved. Optimal OS should help to maximize the number of oocytes, thus improving preclinical laboratory outcomes. Optimal preclinical outcomes should ultimately lead to clinical outcomes with maximal efficacy, safety, and cost-effectiveness. To help guide successful OS, this review details prognostic factors and appropriate endpoints for an optimal OS at each stage of the IVF cycle.
卵巢刺激(OS)是临床体外受精(IVF)治疗的关键组成部分,对治疗结果有重大影响。因此,了解IVF过程中成功进行卵巢刺激的指标很有帮助。由于卵巢刺激会促使多个卵泡募集,因此可以通过获取的卵母细胞数量来进行量化。最佳的卵巢刺激应有助于使卵母细胞数量最大化,从而改善临床前实验室结果。最佳的临床前结果最终应带来具有最大疗效、安全性和成本效益的临床结果。为了指导成功的卵巢刺激,本综述详细介绍了IVF周期各阶段最佳卵巢刺激的预后因素和适当的终点指标。