Guerreiro D, Page C P
Lab Anim. 1987 Jul;21(3):205-9. doi: 10.1258/002367787781268819.
A technique of neuroleptanalgesia during which rabbits breathed spontaneously for as long as 6 h without any outward sign of stress and with full recovery within 12 h is described. The method involved the constant infusion of a solution comprising fentanyl (0.05 mg/ml) and droperidol (0.13 mg/ml) in 5% dextrose following an intramuscular dose of fentanyl and droperidol. Hourly measurements of blood gases, lung mechanics, mean arterial blood pressure and heart rate were made to assess changes in ventilation and in these physiological parameters for the length of the study. The animals' tracheas were intubated under direct vision with an uncuffed tube. The animals breathed spontaneously and their cardiovascular and respiratory systems were stable throughout the entire monitoring period. There was no statistical difference between the values for all the parameters measured (P less than 0.1). A two-way analysis of variance statistical test was applied to all the measurements.
本文描述了一种神经安定镇痛技术，在此期间，兔子能自主呼吸长达6小时，无任何应激的外在迹象，且在12小时内完全恢复。该方法包括在肌肉注射芬太尼和氟哌利多后，持续输注含芬太尼（0.05mg/ml）和氟哌利多（0.13mg/ml）的5%葡萄糖溶液。在研究期间，每小时测量血气、肺力学、平均动脉血压和心率，以评估通气及这些生理参数的变化。动物在直视下经无套囊气管插管。动物自主呼吸，在整个监测期内其心血管和呼吸系统均保持稳定。所有测量参数的值之间无统计学差异（P<0.1）。对所有测量数据进行了双向方差分析统计检验。
