Khanna V K, Pleuvry B J
Br J Anaesth. 1978 Sep;50(9):905-12. doi: 10.1093/bja/50.9.905.
The effectiveness of naloxone and doxapram in reversing the respiratory depressant actions of fentanyl and droperidol in the rabbit has been examined. Both drugs did not reverse fully the depression of respiratory frequency produced by the neuroleptanalgesic agents. Doxapram also failed to reverse fully the depression of minute volume produced by fentanyl and droperidol, although naloxone was adequate in this respect. However, analysis of arterialized venous blood showed that both naloxone and doxapram not only prevented the increase in PCO2 caused by fentanyl and droperidol, but caused also a significant decrease. A reduction in PCO2 was seen also when either naloxone or doxapram was given to untreated rabbits. With doxapram this appeared to be a result of pure respiratory stimulation. Naloxone also produced a reduction in standard bicarbonate.
已对纳洛酮和多沙普仑逆转芬太尼和氟哌利多对家兔呼吸抑制作用的效果进行了研究。两种药物均未完全逆转神经安定镇痛剂所引起的呼吸频率降低。多沙普仑也未能完全逆转芬太尼和氟哌利多所引起的每分通气量降低，尽管纳洛酮在这方面是有效的。然而，对动脉化静脉血的分析表明，纳洛酮和多沙普仑不仅能防止芬太尼和氟哌利多所引起的PCO2升高，而且还能使其显著降低。当给未治疗的家兔单独使用纳洛酮或多沙普仑时，也可见PCO2降低。对于多沙普仑，这似乎是单纯呼吸刺激的结果。纳洛酮还使标准碳酸氢盐降低。
