Key Laboratory of Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China.
School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710072, China.
Eur J Med Chem. 2022 Dec 15;244:114843. doi: 10.1016/j.ejmech.2022.114843. Epub 2022 Oct 14.
Cancer seriously endangers human life and health. Recently, the development of AIEgens with aggregation-induced emission (AIE) effect as a new generation of photosensitizers (PSs) to circumvent aggregation-induced fluorescence quenching and reduction of ROS generation has received extensive attention in photodynamic therapy (PDT), a non-invasive anticancer therapy. Rational molecular design can enhance the photosensitization of AIE PSs to achieve effective PDT and can realize the construction of functionalized AIE PSs and synergistic therapy based on AIE PSs. To improve the efficacy of AIE PSs for cancer treatment, many groups have conducted molecular design studies and produced exciting results. This review summarizes the molecular design strategies of three types of AIE PSs for effective photodynamic therapy, focusing on the design strategies of pure organic small molecule type AIE PSs, and reviews the existing design strategies of metal complexes and conjugated polymers. Subsequently, the design strategy to achieve synergistic treatment of AIE PSs from molecular modifications is summarized. The challenges and prospects of the AIE PSs research field are further discussed.
癌症严重威胁着人类的生命和健康。近年来，具有聚集诱导发光（AIE）效应的 AIEgens 作为新一代光动力治疗（PDT）的光敏剂（PSs），可避免聚集诱导荧光猝灭和减少 ROS 的产生，受到广泛关注。合理的分子设计可以增强 AIE PSs 的光致化性能，从而实现有效的 PDT，并可以基于 AIE PSs 实现功能化 AIE PSs 的构建和协同治疗。为了提高 AIE PSs 治疗癌症的疗效，许多研究小组进行了分子设计研究，并取得了令人振奋的成果。本综述总结了三种类型的 AIE PSs 用于有效光动力治疗的分子设计策略，重点介绍了纯有机小分子型 AIE PSs 的设计策略，并回顾了金属配合物和共轭聚合物的现有设计策略。随后，总结了通过分子修饰实现 AIE PSs 协同治疗的设计策略。进一步讨论了 AIE PSs 研究领域的挑战和前景。
