通过热喷雾/质谱法和热喷雾/质谱/质谱法鉴定多西拉敏的两种葡萄糖醛酸代谢物。

Identification of two glucuronide metabolites of doxylamine via thermospray/mass spectrometry and thermospray/mass spectrometry/mass spectrometry.

作者信息

Korfmacher W A, Holder C L, Betowski L D, Mitchum R K

出版信息

J Anal Toxicol. 1987 Jul-Aug;11(4):182-4. doi: 10.1093/jat/11.4.182.

DOI:10.1093/jat/11.4.182

Abstract

Analysis of a high-pressure liquid chromatography fraction containing two urinary glucuronide metabolites of doxylamine by thermospray mass spectrometry (TSP/MS) provided [MH]+ ions for each metabolite. TSP/MS/MS of the [MH]+ ions provided a fragment ion characteristic of these metabolites. The results demonstrate the utility of TSP/MS analysis for biologically derived glucuronide metabolites.

摘要

通过热喷雾质谱法（TSP/MS）对含有多西拉敏两种尿苷酸代谢物的高压液相色谱馏分进行分析，得到了每种代谢物的[MH]+离子。对[MH]+离子进行TSP/MS/MS分析得到了这些代谢物的特征性碎片离子。结果证明了TSP/MS分析在生物衍生的葡糖醛酸代谢物中的实用性。