人体内多西拉敏N-脱烷基代谢产物的体内乙酰化途径鉴定。
Identification in in vivo acetylation pathway for N-dealkylated metabolites of doxylamine in humans.
作者信息
Ganes D A, Midha K K
机构信息
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
出版信息
Xenobiotica. 1987 Aug;17(8):993-9. doi: 10.3109/00498258709044198.
PMID:3673114
Abstract
- Metabolites of doxylamine in human urine were separated by g.l.c. and h.p.l.c. and tentatively identified by their mass spectrometric behaviour. 2. N-Desmethyldoxylamine, N,N-didesmethyldoxylamine and their N-acetyl conjugates were identified. This is believed to be the first report of acetylation in vivo of primary and secondary aliphatic amines in man.
摘要
- 多西拉敏在人尿液中的代谢产物通过气相色谱法（g.l.c.）和高效液相色谱法（h.p.l.c.）进行分离，并根据其质谱行为进行初步鉴定。2. 鉴定出了N-去甲基多西拉敏、N,N-二去甲基多西拉敏及其N-乙酰共轭物。据信这是关于人体内伯胺和仲胺在体内乙酰化的首次报道。
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