Identification in in vivo acetylation pathway for N-dealkylated metabolites of doxylamine in humans.

1. Metabolites of doxylamine in human urine were separated by g.l.c. and h.p.l.c. and tentatively identified by their mass spectrometric behaviour. 2. N-Desmethyldoxylamine, N,N-didesmethyldoxylamine and their N-acetyl conjugates were identified. This is believed to be the first report of acetylation in vivo of primary and secondary aliphatic amines in man.