转座子、基因组完整性与神经退行性变。
Out of LINE: Transposons, genome integrity, and neurodegeneration.
机构信息
Center for Pediatric Neurological Disease Research, St. Jude Translational Neuroscience, Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Center for Pediatric Neurological Disease Research, St. Jude Translational Neuroscience, Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA; St. Jude Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
出版信息
Neuron. 2022 Oct 19;110(20):3217-3219. doi: 10.1016/j.neuron.2022.09.026.
Abnormal activity of LINE-1 transposable elements has been associated with neurological disease. In this issue of Neuron, Takahashi et al. (2022) show that L1 hyperactivity occurs in the neurodegenerative syndrome ataxia telangiectasia and causes ataxia and cerebellar degeneration in mice.
LINE-1 转座元件的异常活性与神经疾病有关。在本期《神经元》杂志中，Takahashi 等人（2022）表明，L1 的过度活跃发生在神经退行性疾病共济失调毛细血管扩张症中，并导致小鼠出现共济失调和小脑退化。
Zotero 插件