Department of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, PR China.
Department of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, PR China.
Biochim Biophys Acta Mol Cell Res. 2023 Jan;1870(1):119381. doi: 10.1016/j.bbamcr.2022.119381. Epub 2022 Oct 17.
Endometriosis, characterized by ectopic endometrium growth in the extrauterine environment, is one of the most notable diseases of the female reproductive system. Worldwide, endometriosis affects nearly 10 % of women in their reproductive years and causes a significant decline in quality of life. Despite extensive investigations of endometriosis over the past years, the mechanisms of endometriosis pathogenesis remain unclear. In recent years, metabolic factors have increasingly been considered factors in endometriosis. There is compelling evidence regarding the progress of endometriosis in the context of severe metabolic dysfunction. Hence, the curative strategies and ongoing attempts to conquer endometriosis might start with metabolic pathways. This review focuses on metabolic mechanisms and summarizes current research progress. These findings provide valuable information for the non-intrusive diagnosis of the disease and may contribute to the understanding of the pathogenesis of endometriosis.
子宫内膜异位症，其特征是异位的子宫内膜在子宫外环境中生长，是女性生殖系统最显著的疾病之一。全世界，子宫内膜异位症影响着近 10%的育龄妇女，导致生活质量显著下降。尽管近年来对子宫内膜异位症进行了广泛的研究，但子宫内膜异位症发病机制仍不清楚。近年来，代谢因素越来越被认为是子宫内膜异位症的一个因素。在严重代谢功能障碍的背景下，子宫内膜异位症的进展有令人信服的证据。因此，治疗策略和征服子宫内膜异位症的持续尝试可能从代谢途径开始。这篇综述重点介绍了代谢机制，并总结了当前的研究进展。这些发现为疾病的非侵入性诊断提供了有价值的信息，并可能有助于理解子宫内膜异位症的发病机制。
