Wang N G, Zhou L F, Guan M H, Lei H P
J Ethnopharmacol. 1987 Jun;20(1):21-4.
(+)-Gossypol has neither antifertility effect nor toxicity at the dosage of 30 mg/kg orally for 14 days in male rats, but slight damage was found in the germinal epithelium of the testis in animals dosed for 4 weeks. (-)-Gossypol at 30 mg/kg orally for 7 days clearly had an antifertility effect in male rats. It appears that (-)-gossypol is the active stereoisomer of racemic gossypol.
（+）-棉酚以30毫克/千克的剂量口服给药14天，对雄性大鼠既无抗生育作用也无毒性，但给药4周的动物睾丸生精上皮出现轻微损伤。（-）-棉酚以30毫克/千克的剂量口服给药7天，对雄性大鼠有明显的抗生育作用。看来（-）-棉酚是消旋棉酚的活性立体异构体。
