Sotelo A, Montalvo I, de la Luz Crail M, González-Garza M T
J Nutr. 1982 Nov;112(11):2052-7. doi: 10.1093/jn/112.11.2052.
It has recently been shown that gossypol, a component of the cottonseed, has clear antifertility properties. The present study was planned to determine whether diets containing cottonseed in different proportions and in nontoxic amounts, could produce infertility in male rats. Diets were formulated with different concentrations of whole cottonseed flour and stock diet (Purina Chow). After 4 weeks of feeding these diets, the male rats were mated with virgin female rats in order to test male fertility rate. Thereafter, the male rats went into a recovery period during which they were fed stock diet for 6 weeks and were again mated after 3 and 6 weeks on this diet. The results show that: 1) infertility was produced by cottonseed flour diets even with a low concentration of gossypol (defatted cottonseed flour); 2) this effect was reversible at least after 6 weeks of gossypol-containing diets, even in the groups fed diets with a high gossypol concentration. The gossypol present in the diets decreases the number and motility of spermatozoa, even when present in concentrations below its toxic level, which may have an important deleterious effect on animal reproduction, since cottonseed is frequently used in the preparation of balanced diets mainly for animal consumption.
最近研究表明，棉籽中的一种成分棉酚具有明显的抗生育特性。本研究旨在确定含有不同比例且无毒量棉籽的日粮是否会导致雄性大鼠不育。用不同浓度的全棉籽粉和基础日粮（普瑞纳饲料）配制日粮。给雄性大鼠喂食这些日粮4周后，将其与未交配过的雌性大鼠交配，以检测雄性大鼠的生育能力。此后，雄性大鼠进入恢复期，在此期间它们被喂食基础日粮6周，并在恢复日粮喂养3周和6周后再次进行交配。结果表明：1）即使棉酚浓度较低（脱脂棉籽粉），棉籽粉日粮也会导致不育；2）至少在喂食含棉酚日粮6周后，这种影响是可逆的，即使在喂食高棉酚浓度日粮的组中也是如此。日粮中的棉酚会减少精子数量和活力，即使其浓度低于毒性水平，这可能会对动物繁殖产生重要的有害影响，因为棉籽常用于配制主要供动物食用的平衡日粮。
