Yao K Q, Gu Q M, Lei H P
J Ethnopharmacol. 1987 Jun;20(1):25-9. doi: 10.1016/0378-8741(87)90115-2.
The effect of (+/-)-, (+)- and (-)-gossypol on testicular lactate dehydrogenase-X (LDH-X) was studied in vitro and in vivo. It was found that racemic gossypol and the two optical enantiomers had similar inhibitory effects on rat testicular LDH-X in vitro. However, neither racemic gossypol nor the enantiomers exhibited an inhibitory effect on testicular LDH-X in vivo. It is concluded that inhibition of testicular LDH-X is not likely to be the mechanism of the antifertility action of gossypol. The inhibition of testicular LDH-X in vitro by all three preparations of gossypol is probably non-specific.
研究了（±）-、（+）-和（-）-棉酚对睾丸乳酸脱氢酶-X（LDH-X）的体内外作用。结果发现，消旋棉酚和两种旋光对映体在体外对大鼠睾丸LDH-X具有相似的抑制作用。然而，消旋棉酚及其对映体在体内均未表现出对睾丸LDH-X的抑制作用。结论是，抑制睾丸LDH-X不太可能是棉酚抗生育作用的机制。三种棉酚制剂在体外对睾丸LDH-X的抑制作用可能是非特异性的。
