Hilbert S L, Ferrans V J, Tomita Y, Eidbo E E, Jones M
J Thorac Cardiovasc Surg. 1987 Sep;94(3):419-29.
Morphologic, chemical, and hemodynamic studies were made of eight prototype polyurethane trileaflet cardiac valve prostheses that had been implanted in juvenile sheep for 17 to 21 weeks in the mitral position. Calcification of the polyurethane leaflet surfaces was the principal finding. Quantitative chemical analyses revealed calcium values with a mean of 42.7 +/- 21 mg/gm dry weight of leaflet. Morphologically, two distinct types of calcification were observed: One was associated with the polyurethane surface or the interface between the leaflet surface and microthrombi or fibrous sheaths; the other was characterized by calcification associated with degenerated cells within thrombotic material and the fibrous sheath. These morphologic findings were in accord with the results of hemodynamic performance studies indicating that these heart valve prostheses had become both stenotic and regurgitant.
对八个原型聚氨酯三叶心脏瓣膜假体进行了形态学、化学和血流动力学研究，这些假体已在幼年绵羊的二尖瓣位置植入17至21周。聚氨酯瓣叶表面钙化是主要发现。定量化学分析显示钙含量平均为每克瓣叶干重42.7±21毫克。在形态学上，观察到两种不同类型的钙化：一种与聚氨酯表面或瓣叶表面与微血栓或纤维鞘之间的界面有关；另一种的特征是钙化与血栓物质和纤维鞘内的退变细胞有关。这些形态学发现与血流动力学性能研究结果一致，表明这些心脏瓣膜假体已出现狭窄和反流。
