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合成心脏瓣膜组织工程支架的开发策略

Strategies for Development of Synthetic Heart Valve Tissue Engineering Scaffolds.

作者信息

Snyder Yuriy, Jana Soumen

机构信息

Department of Bioengineering, University of Missouri, Columbia, MO 65211, USA.

出版信息

Prog Mater Sci. 2023 Oct;139. doi: 10.1016/j.pmatsci.2023.101173. Epub 2023 Jul 26.

DOI:10.1016/j.pmatsci.2023.101173
PMID:37981978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10655624/
Abstract

The current clinical solutions, including mechanical and bioprosthetic valves for valvular heart diseases, are plagued by coagulation, calcification, nondurability, and the inability to grow with patients. The tissue engineering approach attempts to resolve these shortcomings by producing heart valve scaffolds that may deliver patients a life-long solution. Heart valve scaffolds serve as a three-dimensional support structure made of biocompatible materials that provide adequate porosity for cell infiltration, and nutrient and waste transport, sponsor cell adhesion, proliferation, and differentiation, and allow for extracellular matrix production that together contributes to the generation of functional neotissue. The foundation of successful heart valve tissue engineering is replicating native heart valve architecture, mechanics, and cellular attributes through appropriate biomaterials and scaffold designs. This article reviews biomaterials, the fabrication of heart valve scaffolds, and their in-vitro and in-vivo evaluations applied for heart valve tissue engineering.

摘要

目前的临床解决方案，包括用于心脏瓣膜疾病的机械瓣膜和生物人工瓣膜，都存在凝血、钙化、耐久性差以及无法随患者生长等问题。组织工程方法试图通过制造心脏瓣膜支架来解决这些缺点，这些支架可能为患者提供终身解决方案。心脏瓣膜支架是由生物相容性材料制成的三维支撑结构，它为细胞浸润、营养物质和废物运输提供足够的孔隙率，促进细胞黏附、增殖和分化，并允许细胞外基质产生，共同促进功能性新组织的生成。成功的心脏瓣膜组织工程的基础是通过适当的生物材料和支架设计来复制天然心脏瓣膜的结构、力学和细胞特性。本文综述了用于心脏瓣膜组织工程的生物材料、心脏瓣膜支架的制造及其体外和体内评估。

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