Chen Tieyu, Kou Yanyu, Zheng Ruiling, Wang Hailun, Liang Gang
Pharmaceutical College, Guangxi Medical University, Nanning, China.
Front Chem. 2022 Oct 4;10:1013994. doi: 10.3389/fchem.2022.1013994. eCollection 2022.
Fighting against tumors is an ongoing challenge in both medicinal and clinical applications. In recent years, chemotherapy, along with surgery, has significantly improved the situation to prolong life expectancy. Theoretically, and regardless of dosage, we now have drugs that are strong enough to eliminate most tumors. However, due to uncontrollable drug distribution in the body, it is difficult to increase treatment efficiency by simply increasing dosages. For this reason, the need for a drug delivery system that can release "bombs" at the target organ or tissue as precisely as possible has elicited the interest of researchers. In our work, we design and construct a silica-based nanocomposite to meet the above demand. The novel nanocomposite drug carrier can be guided to target tumors or tissue by a magnetic field, since it is constructed with superparamagnetic FeO as the core. The FeO core is clad in a mesoporous silica molecular sieve MCM-41 (represented as MS, in this article), since this MS has enormous ordered hexagonal caves providing sufficient space to hold the drug molecules. To modify the magnetically guided carriers so that they become both magnetically guided and light-responsive, benzophenone hydrazone is coupled into the molecular sieve tunnel. When a certain wavelength of light is imposed on the gating molecules, C=N double bonds vibrate and swing, causing the cavity that holds the drug molecules to change size and open the tunnels. Hence, the nanocomposite has the ability to release loaded drugs with light irradiation. The structure, loading abilities, and the size of the nanocomposite are inspected with a scanning electron microscope, a transmission electron microscope, thermogravimetry analysis, N adsorption/desorption, and dynamic light scattering The biocompatibility and drug molecule controlled release are tested with an SMMC-7721 cell line.
在医学和临床应用中，对抗肿瘤都是一项持续的挑战。近年来，化疗与手术一起显著改善了延长预期寿命的状况。从理论上讲，且不考虑剂量，我们现在拥有足够强大的药物来消除大多数肿瘤。然而，由于药物在体内的分布无法控制，很难通过简单增加剂量来提高治疗效率。因此，需要一种能够尽可能精确地在靶器官或组织释放“炸弹”的药物递送系统，这引发了研究人员的兴趣。在我们的工作中，我们设计并构建了一种基于二氧化硅的纳米复合材料来满足上述需求。这种新型纳米复合药物载体可以通过磁场引导靶向肿瘤或组织，因为它是以超顺磁性FeO为核心构建的。FeO核心包覆有介孔二氧化硅分子筛MCM - 41（在本文中表示为MS），因为这种MS有巨大的有序六边形孔洞，为容纳药物分子提供了足够的空间。为了对磁性引导载体进行修饰，使其兼具磁性引导和光响应性，将二苯甲酮腙偶联到分子筛通道中。当特定波长的光照射到门控分子上时，C=N双键振动并摆动，导致容纳药物分子的空腔改变大小并打开通道。因此，这种纳米复合材料具有在光照射下释放负载药物的能力。用扫描电子显微镜、透射电子显微镜、热重分析、N吸附/解吸和动态光散射来检测纳米复合材料的结构、负载能力和尺寸。用SMMC - 7721细胞系测试其生物相容性和药物分子控释情况。
