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Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine.加纳儿童罹患无并发症疟疾，接受青蒿琥酯-阿莫地喹或青蒿琥酯-甲氟喹治疗的心电图研究。
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伊巴丹大学学院医院重症恶性疟原虫疟疾患儿的心电图特征

Electrocardiographic features in children with severe falciparum malaria at the University College Hospital, Ibadan.

作者信息

Akinkunmi B F, Ogunkunle O O, Akinbami F O, Orimadegun A E

机构信息

Department of Paediatrics and Child Health, University of Medical Sciences, Ondo City, Nigeria.

Department of Paediatrics, University College Hospital Ibadan, Nigeria.

出版信息

Res J Health Sci. 2022;10(3):198-206. doi: 10.4314/rejhs.v10i3.4. Epub 2022 Sep 28.

DOI:10.4314/rejhs.v10i3.4
PMID:36267922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9581379/
Abstract

INTRODUCTION

The high burden of Malaria morbidity and mortality in children is due to its potential to cause multi-organ dysfunction. There is however limited information on the specific electrocardiographic features in falciparum malaria in paediatric age group.

AIM

To investigate the electrocardiographic (ECG) features in children with (complicated) severe malaria (SM) and acute uncomplicated malaria (AUM) at the University College Hospital, Ibadan.

METHODS

This was a comparative cross-sectional study conducted among 398 children with symptomatic and confirmed Plasmodium falciparum malaria and apparently healthy controls. The frequencies of ECG features were described and compared among these children.

RESULTS

The prevalence of ECG abnormality was 79.7% and 63.2% in Severe Malaria SM and Acute uncomplicated malaria AUM patients, respectively. Sinus tachycardia was significantly more frequent in SM than AUM and control groups (p <0.001). The risk of an ECG abnormality was about three times higher in SM than healthy children (p<0.001; OR=2.89;95%CI[1.68,4.99).

CONCLUSION

Severe malaria patients had significant ECG abnormalities (Sinus Tachycardia).

摘要

引言

儿童疟疾发病率和死亡率高是因为其有可能导致多器官功能障碍。然而，关于儿童年龄组恶性疟原虫疟疾的具体心电图特征的信息有限。

目的

在伊巴丹大学学院医院调查患有（复杂型）重症疟疾（SM）和急性非复杂性疟疾（AUM）的儿童的心电图（ECG）特征。

方法

这是一项对398名有症状且确诊为恶性疟原虫疟疾的儿童以及明显健康的对照儿童进行的比较横断面研究。描述并比较了这些儿童的心电图特征频率。

结果

重症疟疾（SM）和急性非复杂性疟疾（AUM）患者的心电图异常患病率分别为79.7%和63.2%。窦性心动过速在SM组中比AUM组和对照组更常见（p<0.001）。SM患者出现心电图异常的风险比健康儿童高约三倍（p<0.001；OR=2.89；95%CI[1.68,4.99]）。

结论

重症疟疾患者有明显的心电图异常（窦性心动过速）。