Sowunmi A, Falade C O, Oduola A M, Ogundahunsi O A, Fehintola F A, Gbotosho G O, Larcier P, Salako L A
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.
Trans R Soc Trop Med Hyg. 1998 Jul-Aug;92(4):446-8. doi: 10.1016/s0035-9203(98)91086-0.
The cardiac effects of halofantrine were assessed in 42 children with acute symptomatic uncomplicated Plasmodium falciparum malaria by electrocardiographic (ECG) and clinical monitoring over a period of 14 d. The children were treated with oral halofantrine 8 mg/kg body weight every 6 h for 3 doses. There was significant prolongation of the P-R interval (compared with the pre-treatment value) only at 8 h after drug administration. However, first degree auriculoventricular (AV) block occurred in 2 children at 8 h or 8 and 48 h, and second degree AV block in another child at 48 h. There was significant prolongation of the Q-Tc interval at 8, 16, 24, 48 and 72 h after treatment; the proportions of children with Q-Tc interval > 0.44 s were also significantly higher at all these times except 72 h. Rhythm disturbance was rare. There was no significant ECG change at 168 or 336 h. Despite the ECG abnormalities, there was no clinical symptom. These findings indicate that, in children, the currently recommended dose of halofantrine for the treatment of falciparum malaria may produce serious cardiac side effects.
通过心电图（ECG）和临床监测，对42名患有急性症状性单纯恶性疟原虫疟疾的儿童进行了为期14天的卤泛群心脏效应评估。这些儿童接受口服卤泛群治疗，剂量为8mg/kg体重，每6小时一次，共3剂。仅在给药后8小时，P-R间期出现显著延长（与治疗前值相比）。然而，2名儿童在8小时或8小时及48小时出现一度房室（AV）传导阻滞，另一名儿童在48小时出现二度AV传导阻滞。治疗后8、16、24、48和72小时，Q-Tc间期显著延长；除72小时外，所有这些时间Q-Tc间期>0.44秒的儿童比例也显著更高。心律失常很少见。在168或336小时时，心电图无显著变化。尽管有心电图异常，但无临床症状。这些发现表明，在儿童中，目前推荐的卤泛群治疗恶性疟疾剂量可能会产生严重的心脏副作用。
