Hao Xiaoyan, He Honghai, Tao Liyuan, Wang Hongli, Zhao Lili, Ren Yi, Wang Peng
Medical Examination Center, Peking University, Third Hospital, Beijing, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Oct 19;15:3195-3203. doi: 10.2147/DMSO.S379897. eCollection 2022.
This study investigated blood pressure and ventilation efficiency by cardiopulmonary exercise test (CPX) in different types of obesity aged 40-60 years.
The inclusion criteria of this cross-sectional study were adults aged 40-60 years underwent health checks. CPX was measured according to the relevant standards. According to different body mass index (BMI), there were 3 groups, BMI<24 (kg/m), 24≤BMI<28 (kg/m) and BMI≥28 (kg/m). There were two groups in male, waist circumference≥90 (cm) and waist circumference<90 (cm). Similarly, there were two groups in female, waist circumference≥85 (cm) and waist circumference<85 (cm).
There were 543 individuals (64.6% male and 35.4% female) aged 40-60 years in this study. The resting blood pressure (BP) and peak BP have the significant differences in different BMI groups (p < 0.001) and male or female groups (p < 0.001). However, the resting DBP (77.70±9.45 vs 81.16±8.80, p < 0.001) and peak DBP (85.67±10.21 vs 89.03±9.94, p = 0.002) have the significant differences in different male waist circumference groups, and the resting BP (SBP 113.76±14.29 vs 121.86±15.54, p = 0.001, DBP 71.95±10.83 vs 77.27±11.42, p = 0.005) has the significant differences in different female waist circumference groups. Carbon dioxide Ventilation equivalent (VE/VCO) has the significant differences in different male waist circumference groups (26.84±3.10 vs 27.68±2.93, p = 0.009), but it has not the significant differences in different BMI groups and different female waist circumference groups. The oxygen pulse (VO/HR) is slightly higher in female group than male group (0.93±0.15 vs 0.89±0.15, p = 0.001). Breathing reserve has the statistical significance in BMI ≥28 group compared with the BMI <24 group (0.52±0.13 vs 0.46±0.17, ηp=0.021).
We found that the blood pressure and ventilation efficiency of CPX were different between the obesity and normal. This will provide a basis for accurate cardiopulmonary assessment of obesity.
本研究通过心肺运动试验（CPX）调查40至60岁不同类型肥胖者的血压和通气效率。
本横断面研究的纳入标准为40至60岁接受健康检查的成年人。CPX根据相关标准进行测量。根据不同的体重指数（BMI），分为3组，BMI<24（kg/m²）、24≤BMI<28（kg/m²）和BMI≥28（kg/m²）。男性分为两组，腰围≥90（cm）和腰围<90（cm）。同样，女性分为两组，腰围≥85（cm）和腰围<85（cm）。
本研究纳入了543名40至60岁的个体（男性占64.6%，女性占35.4%）。静息血压（BP）和峰值血压在不同BMI组（p<0.001）以及男性或女性组（p<0.001）中存在显著差异。然而，静息舒张压（77.70±9.45 vs 81.16±8.80，p<0.001）和峰值舒张压（85.67±10.21 vs 89.03±9.94，p = 0.002）在不同男性腰围组中存在显著差异，静息血压（收缩压113.76±14.29 vs 121.86±15.54，p = 0.001，舒张压71.95±10.83 vs 77.27±11.42，p = 0.005）在不同女性腰围组中存在显著差异。二氧化碳通气当量（VE/VCO）在不同男性腰围组中存在显著差异（26.84±3.10 vs 27.68±2.93，p = 0.009），但在不同BMI组和不同女性腰围组中无显著差异。女性组的氧脉搏（VO/HR）略高于男性组（0.93±0.15 vs 0.89±0.15，p = 0.001）。与BMI<24组相比，BMI≥28组的呼吸储备具有统计学意义（0.52±0.13 vs 0.46±0.17，ηp=0.021）。
我们发现肥胖者与正常者在CPX的血压和通气效率方面存在差异。这将为肥胖者的准确心肺评估提供依据。
