Pahari Soumya, Shrestha Manju, Basukala Sunil, Kafle Pooja, Rai Kalpana, Khand Yugant, Thapa Ojas, Thapa Anup
Nepalese Army Institute of Health Sciences (NAIHS), Sanobharyang, 44600, Kathmandu, Nepal.
Children's Hospital for Eye Ent & Rehabilitation Services (CHEERS), Kathmandu, Nepal.
Ann Med Surg (Lond). 2022 Sep 23;82:104744. doi: 10.1016/j.amsu.2022.104744. eCollection 2022 Oct.
Pylephlebitis is a rare and life threatening thrombophlebitis of the portal vein. It commonly occurs following intra abdominal infections like appendicitis.It is even rarer in the pediatric age group. The nonspecific presentation impedes the diagnosis. Timely use of appropriate antibiotics and control of infection is paramount in its treatment and this case report highlights the same.
11 year old female child from a rural area was referred from a local hospital for persistent fever and abdominal pain despite medical treatment. Workup revealed perforated appendicitis, pylephlebitis, and multiple liver abscess. She was successfully treated with appendicectomy followed by antibiotics and anticoagulants.
Pylephlebitis secondary to appendicitis was frequently lethal in the pre-antibiotic era. Doppler ultrasonography and CT scan are the investigations of choice to establish the diagnosis by showing a thrombus in the portal vein. With use of antibiotics, early diagnosis by imaging and surgical control of the primary infection, appendicitis-associated-pylephlebitis now has improved outcomes. Larger scale studies are required to establish the role of anticoagulants.
Early diagnosis and intervention of this fatal condition is life saving but numerous gaps exist in the literature regarding the treatment recommendation.
门静脉炎是一种罕见且危及生命的门静脉血栓性静脉炎。它通常发生在腹腔内感染(如阑尾炎)之后。在儿童年龄组中更为罕见。非特异性表现妨碍了诊断。及时使用适当的抗生素和控制感染对其治疗至关重要,本病例报告突出了这一点。
一名来自农村地区的11岁女童因尽管接受了治疗仍持续发热和腹痛,从当地医院转诊而来。检查发现有穿孔性阑尾炎、门静脉炎和多个肝脓肿。她通过阑尾切除术后接受抗生素和抗凝剂治疗而成功康复。
在抗生素出现之前,阑尾炎继发的门静脉炎常常是致命的。多普勒超声检查和CT扫描是通过显示门静脉内血栓来确立诊断的首选检查方法。随着抗生素的使用、通过影像学进行早期诊断以及对原发性感染进行手术控制,与阑尾炎相关的门静脉炎现在有了更好的治疗结果。需要进行更大规模的研究来确定抗凝剂的作用。
对这种致命疾病进行早期诊断和干预可挽救生命,但关于治疗建议,文献中存在许多空白。