维生素D状态也会影响儿童人群的新冠疫情结局。
Vitamin D status can affect COVID-19 outcomes also in pediatric population.
作者信息
Miraglia Del Giudice Michele, Indolfi Cristiana, Dinardo Giulio, Decimo Fabio, Decimo Alberto, Klain Angela
机构信息
Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
出版信息
PharmaNutrition. 2022 Dec;22:100319. doi: 10.1016/j.phanu.2022.100319. Epub 2022 Oct 14.
BACKGROUND
vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D's role in the pathophysiology of COVID-19 disease.
RESULTS
the findings obtained from clinical trials and systematic reviews highlight that most patients with COVID-19 have decreased vitamin D levels and low levels of vitamin D increase the risk of severe disease. This evidence seems to be also confirmed in the pediatric population.
CONCLUSIONS
further studies (systematic review and meta-analysis) conducted on children are needed to confirm that vitamin D affects COVID-19 outcomes and to determine the effectiveness of supplementation and the appropriate dose, duration and mode of administration.
背景
维生素D影响免疫系统和炎症反应。已知补充维生素D可降低急性呼吸道感染的风险。在过去两年中，许多研究人员调查了维生素D在新冠病毒病病理生理学中的作用。
结果
从临床试验和系统评价中获得的研究结果表明，大多数新冠病毒病患者的维生素D水平降低，而低水平的维生素D会增加患重症的风险。这一证据似乎在儿科人群中也得到了证实。
结论
需要对儿童进行进一步的研究（系统评价和荟萃分析），以确认维生素D对新冠病毒病预后的影响，并确定补充剂的有效性以及合适的剂量、疗程和给药方式。
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