Department of Food Science and Engineering, Jinan University, Guangzhou, Guangdong, 510632, China.
Food Funct. 2022 Nov 14;13(22):11592-11603. doi: 10.1039/d2fo01951e.
Aging is a natural process in which the structural integrity of an organism declines over time. The anti-aging activities in () of 5 different edible fungal polysaccharides (EFPs) fermented by human feces were compared. The metabolites and microbial structure within the selected fermented polysaccharide solution were further analyzed using 16S rDNA sequencing and non-targeted metabolomics. The results showed that the fermented EFPs exhibited different anti-aging activities, and fermented polysaccharides (FLAP) and polysaccharides (FHSP) were the best two. Beneficial bacteria ( and ) and metabolites with antioxidant, anti-inflammatory and immune-protective effects (ergothioneine, oleic acid and notoginsenoside R10) were positively correlated and enriched in FLAP and FHSP. These metabolites might have been generated by those bacteria and could be responsible for a significant anti-aging effect. Therefore, the anti-aging potency of the fermented EFPs correlates with metabolites during fermentation using human fecal intestinal microflora.
衰老是一个自然的过程，随着时间的推移，生物体的结构完整性会下降。本研究比较了 5 种不同的人粪便发酵食用真菌多糖（EFPs）的抗衰老活性。进一步采用 16S rDNA 测序和非靶向代谢组学分析了选定发酵多糖溶液中的代谢物和微生物结构。结果表明，发酵的 EFPs 表现出不同的抗衰老活性，发酵多糖（FLAP）和发酵多糖（FHSP）是最好的两种。具有抗氧化、抗炎和免疫保护作用的有益细菌（和）和代谢物（麦角硫因、油酸和三七皂苷 R10）呈正相关，并在 FLAP 和 FHSP 中富集。这些代谢物可能是由这些细菌产生的，可能是其具有显著抗衰老作用的原因。因此，利用人类粪便肠道微生物菌群发酵 EFPs 的抗衰老能力与发酵过程中的代谢物有关。
