College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Carbohydr Polym. 2021 Dec 1;273:118558. doi: 10.1016/j.carbpol.2021.118558. Epub 2021 Aug 14.
The plasticity of the gut microbiota (GM) creates an opportunity to reshape the biological output of gut microbes by manipulating external factors. It is well known that edible fungal polysaccharides (EFPs) can reach the distal intestine and be assimilated to reshape the GM. The GM has unique devices that utilize various EFPs and produce oligosaccharides, which can selectively promote the growth of beneficial bacteria and are fermented into short-chain fatty acids that interact closely with intestinal cells. Here we review EFPs-based interventions for the GM, particularly the key microorganisms, functions, and metabolites. In addition, we discuss the bi-directional causality between GM imbalance and diseases, and the beneficial effects of EFPs on host health via GM. This review can offer a valuable reference for the design of edible fungal polysaccharide- or oligosaccharide-based nutrition interventions or drug development for maintaining human health by targeted regulation of the GM.
肠道微生物群（GM）的可塑性为通过操纵外部因素来重塑肠道微生物的生物学输出创造了机会。众所周知，食用真菌多糖（EFPs）可以到达远端肠道并被吸收，从而重塑 GM。GM 具有独特的装置，可以利用各种 EFPs 并产生寡糖，这些寡糖可以选择性地促进有益细菌的生长，并发酵成短链脂肪酸，与肠道细胞密切相互作用。在这里，我们综述了基于 EFPs 的 GM 干预措施，特别是关键微生物、功能和代谢物。此外，我们还讨论了 GM 失衡与疾病之间的双向因果关系，以及 EFPs 通过 GM 对宿主健康的有益影响。本综述可为设计基于食用真菌多糖或寡糖的营养干预措施或药物开发提供有价值的参考，通过靶向调节 GM 来维持人类健康。
