Quintessence Int. 2023 Jan 13;54(1):24-32. doi: 10.3290/j.qi.b3479957.
To evaluate the benefits of submucosal administration of a dexamethasone and articaine mixture on postoperative pain after mandibular third molar extraction.
This was a double-blind randomized controlled pilot trial of consecutive patients requiring surgical removal of mandibular third molars. Immediately post extraction, the surgeon administered a submucosal injection. The surgeon was masked to the content of the injection, which contained either a mixture of 10 mg dexamethasone and 68 mg articaine ("study group") or the same volume of saline only ("control group"). Pain severity was assessed by questionnaire (postoperative symptom severity [PoSSe] scale) 7 days after the procedure.
Sixty subjects were enrolled. Patients in the study group had significantly lower PoSSe pain intensity scores than subjects in the control group (P = .004). The combined postoperative PoSSe pain score was significantly lower in the study group than in the control group (P = .016). There was no significant difference in pain duration between the two groups (P = .237).
Submucosal injection of dexamethasone/articaine solution after surgical extraction of mandibular third molars is effective in reducing pain intensity.
评估在下颌第三磨牙拔除术后，黏膜下给予地塞米松和阿替卡因混合物对术后疼痛的益处。
这是一项连续患者接受下颌第三磨牙手术切除的双盲随机对照初步试验。在拔除后立即，外科医生进行黏膜下注射。外科医生对注射内容物（含有 10 毫克地塞米松和 68 毫克阿替卡因的混合物[研究组]或相同体积的生理盐水[对照组]）进行了盲法处理。术后 7 天通过问卷（术后症状严重程度[PoSSe]量表）评估疼痛严重程度。
共纳入 60 名受试者。与对照组相比，研究组患者的 PoSSe 疼痛强度评分显著降低（P =.004）。研究组的联合术后 PoSSe 疼痛评分明显低于对照组（P =.016）。两组的疼痛持续时间无显著差异（P =.237）。
在下颌第三磨牙拔除术后黏膜下注射地塞米松/阿替卡因溶液可有效减轻疼痛强度。
