Gordon C J, Workman R A, Highfill J
Neurotoxicol Teratol. 1987 May-Jun;9(3):193-6. doi: 10.1016/0892-0362(87)90002-x.
Several reports in the literature suggest a relationship between lead intoxication and thermoregulatory capacity. To investigate the effects of lead on the control of body temperature, mice of the BALB/c strain were injected intraperitoneally with lead acetate (0 to 100 mg/kg) while colonic temperature was measured 30, 60, and 90 min post-injection at ambient temperatures (Ta) of 20 and 30 degrees C. Lead acetate caused a transient hypothermia, an effect which was augmented at cooler Ta's. In a second experiment, mice were injected with 100 mg/kg lead acetate and placed in a longitudinal temperature gradient to measure their preferred Ta. Lead acetate significantly reduced the preferred Ta during the first 30 min post-injection which augmented the lead-induced hypothermia. In a third experiment it was found that lead acetate-induced lethality was potentiated with increasing Ta. Hence, the hypothermic response to acute lead acetate treatment may be beneficial to survival.
文献中的几篇报道表明铅中毒与体温调节能力之间存在关联。为了研究铅对体温控制的影响，给BALB/c品系的小鼠腹腔注射醋酸铅（0至100毫克/千克），同时在20摄氏度和30摄氏度的环境温度下，于注射后30、60和90分钟测量结肠温度。醋酸铅引起短暂的体温过低，在较冷的环境温度下这种效应会增强。在第二个实验中，给小鼠注射100毫克/千克的醋酸铅，并将其置于纵向温度梯度中以测量它们偏好的环境温度。醋酸铅在注射后的前30分钟显著降低了偏好的环境温度，这增强了铅诱导的体温过低。在第三个实验中发现，随着环境温度升高，醋酸铅诱导的致死率增强。因此，对急性醋酸铅处理的体温过低反应可能对生存有益。
