硒补充剂摄入和血清抗氧化剂浓度对结直肠腺瘤异时性发生的影响修饰。
Effect Modification of Selenium Supplementation by Intake and Serum Concentrations of Antioxidants on the Development of Metachronous Colorectal Adenoma.
机构信息
University of Arizona Cancer Center, University of Arizona, Tucson, Arizona.
Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona.
出版信息
Nutr Cancer. 2023;75(2):552-561. doi: 10.1080/01635581.2022.2135745. Epub 2022 Oct 22.
BACKGROUND
Selenium (Se) is a trace element that has been investigated as a potential chemopreventive agent for colorectal cancer. Dietary intake of other antioxidant nutrients may modify the effect of Se.
OBJECTIVE
We examined the association between intake and serum concentrations of retinol, β-carotene, β-cryptoxanthin, lycopene, lutein/zeaxanthin, and α- and γ-tocopherol and the development of metachronous colorectal adenoma, and if these nutrients modified the effect of Se.
METHODS
We conducted a prospective study of 1874 participants from the Se Trial with data for antioxidant intake, as well as a subcohort of 508 participants with serum biomarker concentrations.
RESULTS
Statistically significantly lower odds for the development of metachronous adenoma were observed for those participants in the highest tertile of intake for lutein/zeaxanthin compared to the lowest, with an OR (95% CI) of 0.72 (0.56-0.94). No effect modification for intake of any nutrient was observed. However, circulating concentrations of lycopene exhibited statistically significant effect modification of selenium supplementation ( < 0.06).
CONCLUSION
These findings show that intake and circulating concentrations of antioxidant nutrients were not consistently associated with reduced odds for the development of metachronous lesions, although blood concentrations of lycopene may modify the effect of selenium supplementation.
背景
硒（Se）是一种微量元素，已被研究作为结直肠癌的潜在化学预防剂。其他抗氧化营养素的饮食摄入可能会改变硒的作用。
目的
我们研究了视黄醇、β-胡萝卜素、β-隐黄质、番茄红素、叶黄素/玉米黄质、α-和γ-生育酚的摄入量和血清浓度与结直肠腺瘤的发生之间的关系，以及这些营养素是否会改变硒的作用。
方法
我们对来自硒试验的 1874 名参与者进行了前瞻性研究，这些参与者的数据包括抗氧化剂的摄入量，以及 508 名参与者的血清生物标志物浓度的亚队列。
结果
与最低摄入量组相比，摄入最高三分位的叶黄素/玉米黄质的参与者发生结直肠腺瘤的几率明显降低，比值比（95%置信区间）为 0.72（0.56-0.94）。没有观察到任何营养素摄入的效应修饰。然而，循环番茄红素浓度对硒补充剂的作用有统计学意义的修饰（<0.06）。
结论
这些发现表明，抗氧化营养素的摄入量和循环浓度与减少结直肠腺瘤发生的几率没有一致的关联，尽管番茄红素的血液浓度可能会修饰硒补充剂的作用。
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