Gueguen Sonia, Pirollet Pascal, Leroy Pierre, Guilland Jean-Claude, Arnaud Josiane, Paille François, Siest Gérard, Visvikis Sophie, Hercberg Serge, Herbeth Bernard
INSERM U525 and Centre de Médecine Préventive, 2 avenue Jacques Parisot, F-54500 Vandoeuvre-lès-Nancy, France.
J Am Coll Nutr. 2003 Aug;22(4):303-10. doi: 10.1080/07315724.2003.10719308.
To test the effect of a 21-day supplementation with moderate doses of antioxidant nutrients on biochemical indicators of vitamin, carotenoid and trace element levels in alcohol-dependent patients during a program of alcohol rehabilitation.
A randomized double-blind trial was performed comparing two groups receiving daily either a combination of micronutrients (beta-carotene: 6 mg, vitamin C: 120 mg, vitamin E: 30 mg, zinc: 20 mg, selenium: 100 micro g) or a placebo.
106 alcohol-dependent patients 20 to 60 years of age without severe liver disease, hospitalized for a 21-day rehabilitation program. Measure of Outcome: Vitamin C, retinol, alpha-tocopherol, zeaxanthin/lutein, beta-cryptoxanthin, lycopene, alpha- and beta-carotene, zinc and selenium were measured in serum, initially and after supplementation.
(1) In the placebo group, after 21 days of rehabilitation, serum concentrations of vitamin C and all five carotenoids significantly increased, whereas retinol and alpha-tocopherol concentrations decreased; zinc and selenium levels were unaffected. (2) At the end of the hospital stay, serum indicators were significantly improved in the supplement group as compared to the placebo group for vitamin C, alpha-tocopherol, beta-carotene, zinc and selenium; conversely, lycopene changes were higher in the placebo group than in supplement group. (3) Of the serum antioxidants measured at entrance, only vitamin C was significantly depleted in heavy smokers, and, after the supplementation period, vitamin C was efficiently repleted in this later group.
Our results indicate that a short-term supplementation with physiological doses of antioxidant vitamins, carotenoids and trace elements during alcohol rehabilitation clearly improves micronutrient status indicators. Heavy smokers in particular seem to respond to vitamin C supplementation.
测试在酒精依赖患者的酒精康复计划期间，补充21天中等剂量抗氧化营养素对维生素、类胡萝卜素和微量元素水平生化指标的影响。
进行了一项随机双盲试验，比较两组每日分别接受微量营养素组合（β-胡萝卜素：6毫克、维生素C：120毫克、维生素E：30毫克、锌：20毫克、硒：100微克）或安慰剂的情况。
106名年龄在20至60岁之间、无严重肝病的酒精依赖患者，因21天康复计划住院。结果测量：在补充前和补充后，测量血清中的维生素C、视黄醇、α-生育酚、玉米黄质/叶黄素、β-隐黄质、番茄红素、α-和β-胡萝卜素、锌和硒。
（1）在安慰剂组中，康复21天后，血清维生素C和所有五种类胡萝卜素的浓度显著增加，而视黄醇和α-生育酚浓度降低；锌和硒水平未受影响。（2）住院结束时，与安慰剂组相比，补充组的血清指标在维生素C、α-生育酚、β-胡萝卜素、锌和硒方面有显著改善；相反，安慰剂组的番茄红素变化高于补充组。（3）在入院时测量的血清抗氧化剂中，只有维生素C在重度吸烟者中显著缺乏，并且在补充期后，这一群体中的维生素C得到了有效补充。
我们的结果表明，在酒精康复期间短期补充生理剂量的抗氧化维生素类胡萝卜素和微量元素可明显改善微量营养素状态指标。特别是重度吸烟者似乎对维生素C补充有反应。
