Bailie G R, Eisele G, Venezia R A, Yocum D, Hollister A
Department of Pharmacy Practice, Albany College of Pharmacy, New York.
Clin Pharmacokinet. 1992 Apr;22(4):298-307. doi: 10.2165/00003088-199222040-00005.
The pharmacokinetics of vancomycin were studied in continuous ambulatory peritoneal dialysis patients with peritonitis. Six patients received an intraperitoneal loading dose of 15 mg/kg and 4 received an intraperitoneal dose of 25 mg/L. The ability of 2 methods to predict serum concentrations during the loading dose exchange was determined. The mean serum concentration after the exchange was 17.8 +/- 2.2 mg/L in patients receiving the loading dose. The mean dialysis clearance in all patients was 0.94 +/- 0.34 L/h. 66.6 +/- 13.4% of a dose was absorbed into the circulation in 4 h. The volume of distribution was 0.61 +/- 0.46 L/kg, and the half-life for equilibration of vancomycin into the circulation from dialysate was 2.76 +/- 0.94 h. Two methods of predicting serum vancomycin concentrations were tested, with 1 method predicting values significantly different from measured concentrations while the other did not. Serum vancomycin concentrations can be accurately predicted during a loading dose exchange.
对患有腹膜炎的持续性非卧床腹膜透析患者的万古霉素药代动力学进行了研究。6名患者接受了15mg/kg的腹腔负荷剂量，4名患者接受了25mg/L的腹腔剂量。确定了两种方法预测负荷剂量交换期间血清浓度的能力。接受负荷剂量的患者交换后的平均血清浓度为17.8±2.2mg/L。所有患者的平均透析清除率为0.94±0.34L/h。4小时内66.6±13.4%的剂量被吸收进入循环。分布容积为0.61±0.46L/kg，万古霉素从透析液进入循环的平衡半衰期为2.76±0.94小时。测试了两种预测血清万古霉素浓度的方法，一种方法预测的值与测量浓度有显著差异，而另一种方法则没有。在负荷剂量交换期间可以准确预测血清万古霉素浓度。
