细胞内游离钙和肌醇多磷酸的作用作为衰老过程中的潜在靶点。
Intracellular free calcium and inositol polyphosphate action as potential targets in the ageing process.
作者信息
Barritt G J
出版信息
Neurobiol Aging. 1987 Jul-Aug;8(4):357-9. doi: 10.1016/0197-4580(87)90079-0.
PMID:3627353
Abstract
The concentration of free Ca2+ in the cell cytoplasm is likely to be the most important parameter which should be considered in assessing the contribution of Ca2+ to regulation of neurotransmitter release, memory development and cell growth. Quantitative measurement of the free Ca2+ concentration and elucidation of the membrane transduction systems which control this parameter in aged neuronal cells may make a significant contribution to further define the role of Ca2+ in the ageing nervous system.
摘要
细胞质中游离Ca2+的浓度可能是评估Ca2+对神经递质释放、记忆发育和细胞生长调节作用时应考虑的最重要参数。定量测量游离Ca2+浓度并阐明控制老年神经元细胞中这一参数的膜转导系统，可能对进一步明确Ca2+在衰老神经系统中的作用做出重大贡献。
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