Berridge M J, Irvine R F
AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, Cambridge, UK.
Nature. 1989 Sep 21;341(6239):197-205. doi: 10.1038/341197a0.
Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.
肌醇1,4,5-三磷酸是一种第二信使，它通过从内部储存库中释放钙以及可能通过间接刺激钙内流来调节细胞内钙。在这些作用中，它可能与其磷酸化代谢产物肌醇1,3,4,5-四磷酸共同发挥作用。最近的研究强调了肌醇磷酸对钙调节的微妙之处，这些研究揭示了钙浓度的振荡，这可能是频率编码第二信使系统的一部分。
