Aliakbari Fereshteh, Hosseini Jalil, Hashemi Reza, Moamer Soraya, Sadeghzade Zahra, Rezaei-Tazangi Fatemeh, Gelehkolee Keshvar Samadae, Hamdieh Mostafa
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Biostatistics, Student Research Committee, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Andrologia. 2022 Dec;54(11):e14594. doi: 10.1111/and.14594. Epub 2022 Oct 23.
Some studies have shown that Ritalin can interfere with the growth and development of the reproductive system and can also have a serious and harmful effect on sperm parameters, so we decided to conduct studies in this field on the human sample. In a case-control study, 100 adult men aged 21-31 years with hyperactivity were divided into two groups of 50 past users and 50 current users and, 50 patients who had not used Ritalin before were included as the control group. Data were analysed using SPSS software, version 20. Analysis of variance, Pearson correlation coefficient, and regression analysis was used to assess the correlation between variables. The results also showed that there was a statistically significant difference between the current users and the control group in terms of sperm count, abnormality, and motility (p < .47). Comparison of the user group in the past and the control group showed that there was no statistically significant difference in terms of sperm count (p < .59), but there was a significant difference in terms of sperm motility and abnormality between the two groups (p < .001). The present study showed that long-term use of Ritalin can have negative effects on sperm parameters in humans.
一些研究表明，利他林会干扰生殖系统的生长和发育，还会对精子参数产生严重有害影响，因此我们决定针对人体样本在该领域开展研究。在一项病例对照研究中，将100名年龄在21至31岁之间的患有多动症状的成年男性分为两组，每组50人，一组为曾使用过利他林的人群，另一组为当前正在使用利他林的人群，另外选取50名此前未使用过利他林的患者作为对照组。使用SPSS 20版软件对数据进行分析。采用方差分析、皮尔逊相关系数和回归分析来评估变量之间的相关性。结果还显示，当前使用者与对照组在精子数量、异常情况和活力方面存在统计学上的显著差异（p < 0.47）。过去使用过利他林的人群与对照组的比较表明，在精子数量方面不存在统计学上的显著差异（p < 0.59），但两组在精子活力和异常情况方面存在显著差异（p < 0.001）。本研究表明，长期使用利他林会对人类精子参数产生负面影响。
